Seroatlas · Human Serome Atlas

MMS22L

Protein MMS22-like

Also known as: C6orf167, dJ39B17.2, MMS22_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZRQ5
Gene: MMS22L
Ensembl: ENSG00000146263
Chromosome: 6
Canonical length: 1243 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene forms a complex with tonsoku-like, DNA repair protein (TONSL), and this complex recognizes and repairs DNA double-strand breaks at sites of stalled or collapsed replication forks. The encoded protein also can bind with the histone-associated protein NFKBIL2 to help regulate the chromatin state at stalled replication forks. Finally, this gene appears to be overexpressed in most lung and esophageal cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

1243 residues, UniProt reviewed canonical sequence.

>Q6ZRQ5|MMS22L
     1  MENCSAASTF LTDSLELELG TEWCKPPYFS CAVDNRGGGK HFSGESYLCS GALKRLILNL
    61  DPLPTNFEED TLEIFGIQWV TETALVNSSR ELFHLFRQQL YNLETLLQSS CDFGKVSTLH
   121  CKADNIRQQC VLFLHYVKVF IFRYLKVQNA ESHVPVHPYE ALEAQLPSVL IDELHGLLLY
   181  IGHLSELPSV NIGAFVNQNQ IKLFPPSWHL LHLHLDIHWL VLEILYMLGE KLKQVVYGHQ
   241  FMNLASDNLT NISLFEEHCE TLLCDLISLS LNRYDKVRSS ESLMSDQCPC LCIKELWVLL
   301  IHLLDHRSKW FVSESFWNWL NKLLKTLLEK SSDRRRSSMP VIQSRDPLGF SWWIITHVAS
   361  FYKFDRHGVP DEMRKVESNW NFVEELLKKS ISVQGVILEE QLRMYLHCCL TLCDFWEPNI
   421  AIVTILWEYY SKNLNSSFSI SWLPFKGLAN TMKSPLSMLE MVKTCCCDKQ DQELYKSSSS
   481  YTIFLCILAK VVKKAMKSNG PHPWKQVKGR IYSKFHQKRM EELTEVGLQN FFSLFLLLAA
   541  VAEVEDVASH VLDLLNFLKP AFVTSQRALI WKGHMAFLLM YAQKNLDIGV LAEKFSCAFR
   601  EKAKEFLVSK NEEMVQRQTI WTLLSIYIDG VQEVFETSYC LYPSHEKLLN DGFSMLLRAC
   661  RESELRTVLS FLQAVLARIR SMHQQLCQEL QRDNVDLFVQ SSLSAKERHL AAVASALWRH
   721  FFSFLKSQRM SQVVPFSQLA DAAADFTLLA MDMPSTAPSD FQPQPVISII QLFGWDDIIC
   781  PQVVARYLSH VLQNSTLCEA LSHSGYVSFQ ALTVRSWIRC VLQMYIKNLS GPDDLLIDKN
   841  LEEAVEKEYM KQLVKLTRLL FNLSEVKSIF SKAQVEYLSI SEDPKKALVR FFEAVGVTYG
   901  NVQTLSDKSA MVTKSLEYLG EVLKYIKPYL GKKVFSAGLQ LTYGMMGILV KSWAQIFATS
   961  KAQKLLFRII DCLLLPHAVL QQEKELPAPM LSAIQKSLPL YLQGMCIVCC QSQNPNAYLN
  1021  QLLGNVIEQY IGRFLPASPY VSDLGQHPVL LALRNTATIP PISSLKKCIV QVIRKSYLEY
  1081  KGSSPPPRLA SILAFILQLF KETNTDIYEV ELLLPGILKC LVLVSEPQVK RLATENLQYM
  1141  VKACQVGSEE EPSSQLTSVF RQFIQDYGMR YYYQVYSILE TVATLDQQVV IHLISTLTQS
  1201  LKDSEQKWGL GRNIAQREAY SKLLSHLGQM GQDEMQRLEN DNT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MMS22L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 6.7 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 6.7 nTPM
testis: 6.4 nTPM
thymus: 4.9 nTPM
lymph node: 3.2 nTPM
tonsil: 3.2 nTPM
skin: 2.7 nTPM

Single-cell type

erythrocyte progenitors: 182 nCPM
neutrophil progenitors: 159 nCPM
early primary spermatocytes: 132 nCPM
megakaryocyte progenitors: 120 nCPM
monocyte progenitors: 118 nCPM
late primary spermatocytes: 113 nCPM

Immune cell

non-classical monocyte: 1.6 nTPM
plasmacytoid DC: 1.2 nTPM
myeloid DC: 1.1 nTPM
naive CD8 T-cell: 1.1 nTPM
MAIT T-cell: 1 nTPM
memory CD8 T-cell: 1 nTPM

Brain region

white matter: 7 nTPM
medulla oblongata: 6.7 nTPM
basal ganglia: 5.8 nTPM
pons: 5.8 nTPM
thalamus: 5.2 nTPM
midbrain: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -1.58
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

single-stranded DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

MMS22-like, C-terminal
Protein MMS22-like, N-terminal
Protein MMS22-like
S-phase genomic integrity recombination mediator, N-terminal
S-phase genomic integrity recombination mediator, C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MMS22L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MMS22L as an antibody target. Whether an autoantibody or antibody against MMS22L could matter depends on whether native MMS22L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MMS22L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MMS22L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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