Seroatlas · Human Serome Atlas

CDAN1

Codanin-1

Also known as: CDA-I, CDAI, CDAN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWY9
Gene: CDAN1
Ensembl: ENSG00000140326
Chromosome: 15
Canonical length: 1227 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009]

Canonical amino-acid sequenceUniProt

1227 residues, UniProt reviewed canonical sequence.

>Q8IWY9|CDAN1
     1  MAAVLESLLR EEVSVAAVVR WIARSTQGSE DNAGEAAALS SLRALRKEFV PFLLNFLREQ
    61  SSRVLPQGPP TPAKTPGASA ALPGRPGGPP RGSRGARSQL FPPTEAQSTA AEAPLARRGG
   121  RRRGPGPARE RGGRGLEEGV SGESLPGAGG RRLRGSGSPS RPSLTLSDPP NLSNLEEFPP
   181  VGSVPPGPTG TKPSRRINPT PVSEERSLSK PKTCFTSPPI SCVPSSQPSA LDTSPWGLGL
   241  PPGCRSLQEE REMLRKERSK QLQQSPTPTC PTPELGSPLP SRTGSLTDEP ADPARVSSRQ
   301  RLELVALVYS SCIAENLVPN LFLELFFVFQ LLTARRMVTA KDSDPELSPA VLDSLESPLF
   361  QSIHDCVFFA VQVLECHFQV LSNLDKGTLK LLAENERLLC FSPALQGRLR AAYEGSVAKV
   421  SLVMPPSTQA VSFQPETDNR ANFSSDRAFH TFKKQRDVFY EVLREWEDHH EEPGWDFEKG
   481  LGSRIRAMMG QLSAACSHSH FVRLFQKQLL QMCQSPGGAG GTVLGEAPDV LSMLGADKLG
   541  RLWRLQERLM APQSSGGPCP PPTFPGCQGF FRDFILSASS FQFNQHLMDS LSLKIQELNG
   601  LALPQHEPND EDGESDVDWQ GERKQFAVVL LSLRLLAKFL GFVAFLPYRG PEPPPTGELQ
   661  DSILALRSQV PPVLDVRTLL QRGLQARRAV LTVPWLVEFL SFADHVVPLL EYYRDIFTLL
   721  LRLHRSLVLS QESEGKMCFL NKLLLLAVLG WLFQIPTVPE DLFFLEEGPS YAFEVDTVAP
   781  EHGLDNAPVV DQQLLYTCCP YIGELRKLLA SWVSGSSGRS GGFMRKITPT TTTSLGAQPS
   841  QTSQGLQAQL AQAFFHNQPP SLRRTVEFVA ERIGSNCVKH IKATLVADLV RQAESLLQEQ
   901  LVTQGEEGGD PAQLLEILCS QLCPHGAQAL ALGREFCQRK SPGAVRALLP EETPAAVLSS
   961  AENIAVGLAT EKACAWLSAN ITALIRREVK AAVSRTLRAQ GPEPAARGER RGCSRACEHH
  1021  APLPSHLISE IKDVLSLAVG PRDPDEGVSP EHLEQLLGQL GQTLRCRQFL CPPAEQHLAK
  1081  CSVELASLLV ADQIPILGPP AQYRLERGQA RRLLHMLLSL WKEDFQGPVP LQLLLSPRNV
  1141  GLLADTRPRE WDLLLFLLRE LVEKGLMGRM EIEACLGSLH QAQWPGDFAE ELATLSNLFL
  1201  AEPHLPEPQL RACELVQPNR GTVLAQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDAN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 9.1 nTPM

Expression across tissuesHPA

Tissue

ovary: 9.1 nTPM
bone marrow: 7.6 nTPM
cerebellum: 6.4 nTPM
cervix: 6.1 nTPM
prostate: 5.8 nTPM
endometrium: 5.3 nTPM

Single-cell type

rod photoreceptor cells: 22 nCPM
adrenal medulla cells: 21 nCPM
medullary thymic epithelial cells: 19 nCPM
fibro-adipogenic progenitors: 18 nCPM
müller glia: 18 nCPM
leydig cells: 17 nCPM

Immune cell

basophil: 1 nTPM
eosinophil: 0.5 nTPM
plasmacytoid DC: 0.2 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

cerebellum: 17 nTPM
cerebral cortex: 14 nTPM
choroid plexus: 14 nTPM
medulla oblongata: 14 nTPM
pons: 14 nTPM
white matter: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDAN1.

Disease | AllUniProt

Conditions CDAN1 is implicated in, by any mechanism.

Anemia, congenital dyserythropoietic, 1A (CDAN1A) MIM:224120

Disease | GeneticClinVar

66 pathogenic / likely-pathogenic of 933 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Anemia, congenital dyserythropoietic, type 1a
Congenital dyserythropoietic anemia, type I
CDAN1-related disorder
Uterine corpus endometrial carcinoma
Cervical cancer

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: -0.94
DepMap mean gene effect: -0.84
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Codanin-1, C-terminal domain
Codanin-1
Codanin-1 C-terminus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDAN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDAN1 as an antibody target. Whether an autoantibody or antibody against CDAN1 could matter depends on whether native CDAN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDAN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDAN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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