PAWR

Protein identityUniProt · HPA

UniProt accession

Q96IZ0

Gene

PAWR

Ensembl

ENSG00000177425

Chromosome

12

Canonical length

340 aa

Protein class

Predicted intracellular proteins

Subcellular location

Plasma membrane,Actin filaments,Primary cilium tip,Cytosol

Quaternary structure

Homooligomer

OverviewNCBI Gene

This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>Q96IZ0|PAWR
     1  MATGGYRTSS GLGGSTTDFL EEWKAKREKM RAKQNPPGPA PPGGGSSDAA GKPPAGALGT
    61  PAAAAANELN NNLPGGAPAA PAVPGPGGVN CAVGSAMLTR AAPGPRRSED EPPAASASAA
   121  PPPQRDEEEP DGVPEKGKSS GPSARKGKGQ IEKRKLREKR RSTGVVNIPA AECLDEYEDD
   181  EAGQKERKRE DAITQQNTIQ NEAVNLLDPG SSYLLQEPPR TVSGRYKSTT SVSEEDVSSR
   241  YSRTDRSGFP RYNRDANVSG TLVSSSTLEK KIEDLEKEVV RERQENLRLV RLMQDKEEMI
   301  GKLKEEIDLL NRDLDDIEDE NEQLKQENKT LLKVVGQLTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAWR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.64

Highest tissue expression

26 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.7

gnomAD pLI

0.09

gnomAD missense Z

0.5

DepMap mean gene effect

0.12

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin filament bundle assembly
• apoptotic process
• apoptotic signaling pathway
• negative regulation of B cell proliferation
• negative regulation of fibroblast proliferation
• negative regulation of gene expression
• negative regulation of T cell proliferation
• negative regulation of T cell receptor signaling pathway
• negative regulation of transcription by RNA polymerase II
• positive regulation of amyloid precursor protein biosynthetic process
• positive regulation of apoptotic process
• positive regulation of cellular senescence
• positive regulation of gene expression
• positive regulation of hydrogen peroxide-mediated programmed cell death

Molecular functions

• actin binding
• enzyme binding
• leucine zipper domain binding
• transcription corepressor activity

Cellular components

• actin cytoskeleton
• actin filament
• chromatin
• ciliary tip
• cytoplasm
• cytosol
• nucleus
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Prostate apoptosis response 4

KeywordsUniProt

• Apoptosis
• Coiled coil
• Cytoplasm
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of PAWR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AATF
• BACE1
• SPSB1
• SPSB2
• SPSB4
• THAP1
• DAPK3
• HMG20A
• HSPA5