Seroatlas · Human Serome Atlas

MAPT

Microtubule-associated protein tau

Also known as: DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, PPP1R103, tau, TAU_HUMAN, tau-40

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P10636
Gene
MAPT
Ensembl
ENSG00000186868
Chromosome
17
Canonical length
758 aa
Protein class
Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Nuclear speckles,Plasma membrane,End piece
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

758 residues, UniProt reviewed canonical sequence.

>P10636|MAPT
     1  MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG
    61  SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG
   121  HVTQEPESGK VVQEGFLREP GPPGLSHQLM SGMPGAPLLP EGPREATRQP SGTGPEDTEG
   181  GRHAPELLKH QLLGDLHQEG PPLKGAGGKE RPGSKEEVDE DRDVDESSPQ DSPPSKASPA
   241  QDGRPPQTAA REATSIPGFP AEGAIPLPVD FLSKVSTEIP ASEPDGPSVG RAKGQDAPLE
   301  FTFHVEITPN VQKEQAHSEE HLGRAAFPGA PGEGPEARGP SLGEDTKEAD LPEPSEKQPA
   361  AAPRGKPVSR VPQLKARMVS KSKDGTGSDD KKAKTSTRSS AKTLKNRPCL SPKHPTPGSS
   421  DPLIQPSSPA VCPEPPSSPK YVSSVTSRTG SSGAKEMKLK GADGKTKIAT PRGAAPPGQK
   481  GQANATRIPA KTPPAPKTPP SSGEPPKSGD RSGYSSPGSP GTPGSRSRTP SLPTPPTREP
   541  KKVAVVRTPP KSPSSAKSRL QTAPVPMPDL KNVKSKIGST ENLKHQPGGG KVQIINKKLD
   601  LSNVQSKCGS KDNIKHVPGG GSVQIVYKPV DLSKVTSKCG SLGNIHHKPG GGQVEVKSEK
   661  LDFKDRVQSK IGSLDNITHV PGGGNKKIET HKLTFRENAK AKTDHGAEIV YKSPVVSGDT
   721  SPRHLSNVSS TGSIDMVDSP QLATLADEVS ASLAKQGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAPT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.72
Highest tissue expression
148 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 148 nTPM
  • cerebellum: 139 nTPM
  • hippocampal formation: 97 nTPM
  • hypothalamus: 97 nTPM
  • amygdala: 97 nTPM
  • skeletal muscle: 84 nTPM

Single-cell type

  • oligodendrocytes: 379 nCPM
  • brain excitatory neurons: 320 nCPM
  • astrocytes: 296 nCPM
  • other brain neurons: 295 nCPM
  • brain inhibitory neurons: 251 nCPM
  • bergmann glia: 241 nCPM

Immune cell

  • non-classical monocyte: 1.7 nTPM
  • intermediate monocyte: 0.7 nTPM
  • T-reg: 0.7 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • gdT-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM

Brain region

  • cerebral cortex: 250 nTPM
  • basal ganglia: 169 nTPM
  • pons: 162 nTPM
  • hypothalamus: 156 nTPM
  • white matter: 155 nTPM
  • midbrain: 148 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAPT.

Disease | AllUniProt

Conditions MAPT is implicated in, by any mechanism.

Disease | GeneticClinVar

38 pathogenic / likely-pathogenic of 592 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0.01
gnomAD missense Z
1.52
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAPT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAPT as an antibody target. Whether an autoantibody or antibody against MAPT could matter depends on whether native MAPT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAPT is annotated at the cell surface, where native MAPT is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MAPT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAPT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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