Receptor Tyrosine Kinase
IPR050122
Definition
The receptor tyrosine kinase family plays a crucial role in various cellular processes, including cell proliferation, differentiation, migration, and apoptosis. They act as cell-surface receptors for various ligands, such as fibroblast growth factors, insulin, and other growth factors, triggering intracellular signaling cascades that regulate embryonic development, the immune response, and the nervous system. Mutations or aberrant activation can lead to diseases like cancer. They are involved in angiogenesis, skeletal development, and maintaining vascular stability.
39 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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