ROR1

Protein identityUniProt · HPA

UniProt accession

Q01973

Gene

ROR1

Ensembl

ENSG00000185483

Chromosome

1

Canonical length

937 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

Secretome location

Intracellular and membrane

OverviewNCBI Gene

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

937 residues, UniProt reviewed canonical sequence.

>Q01973|ROR1
     1  MHRPRRRGTR PPLLALLAAL LLAARGAAAQ ETELSVSAEL VPTSSWNISS ELNKDSYLTL
    61  DEPMNNITTS LGQTAELHCK VSGNPPPTIR WFKNDAPVVQ EPRRLSFRST IYGSRLRIRN
   121  LDTTDTGYFQ CVATNGKEVV SSTGVLFVKF GPPPTASPGY SDEYEEDGFC QPYRGIACAR
   181  FIGNRTVYME SLHMQGEIEN QITAAFTMIG TSSHLSDKCS QFAIPSLCHY AFPYCDETSS
   241  VPKPRDLCRD ECEILENVLC QTEYIFARSN PMILMRLKLP NCEDLPQPES PEAANCIRIG
   301  IPMADPINKN HKCYNSTGVD YRGTVSVTKS GRQCQPWNSQ YPHTHTFTAL RFPELNGGHS
   361  YCRNPGNQKE APWCFTLDEN FKSDLCDIPA CDSKDSKEKN KMEILYILVP SVAIPLAIAL
   421  LFFFICVCRN NQKSSSAPVQ RQPKHVRGQN VEMSMLNAYK PKSKAKELPL SAVRFMEELG
   481  ECAFGKIYKG HLYLPGMDHA QLVAIKTLKD YNNPQQWTEF QQEASLMAEL HHPNIVCLLG
   541  AVTQEQPVCM LFEYINQGDL HEFLIMRSPH SDVGCSSDED GTVKSSLDHG DFLHIAIQIA
   601  AGMEYLSSHF FVHKDLAARN ILIGEQLHVK ISDLGLSREI YSADYYRVQS KSLLPIRWMP
   661  PEAIMYGKFS SDSDIWSFGV VLWEIFSFGL QPYYGFSNQE VIEMVRKRQL LPCSEDCPPR
   721  MYSLMTECWN EIPSRRPRFK DIHVRLRSWE GLSSHTSSTT PSGGNATTQT TSLSASPVSN
   781  LSNPRYPNYM FPSQGITPQG QIAGFIGPPI PQNQRFIPIN GYPIPPGYAA FPAAHYQPTG
   841  PPRVIQHCPP PKSRSPSSAS GSTSTGHVTS LPSSGSNQEA NIPLLPHMSI PNHPGGMGIT
   901  VFGNKSQKPY KIDSKQASLL GDANIHGHTE SMISAEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ROR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

23 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ROR1.

Disease | AllUniProt

Conditions ROR1 is implicated in, by any mechanism.

• Deafness, autosomal recessive, 108 (DFNB108) MIM:617654

Disease | ImmuneIEDB

Conditions an epitope on ROR1 was assayed in.

• chronic lymphocytic leukemia T cell
• head and neck squamous cell carcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.27

gnomAD pLI

1

gnomAD missense Z

2.17

DepMap mean gene effect

0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• astrocyte development
• cell population proliferation
• cell surface receptor protein tyrosine kinase signaling pathway
• inner ear development
• positive regulation of canonical NF-kappaB signal transduction
• positive regulation of NF-kappaB transcription factor activity
• sensory perception of sound

Molecular functions

• ATP binding
• coreceptor activity
• signaling receptor activity
• transmembrane receptor protein tyrosine kinase activity
• Wnt receptor activity
• Wnt-protein binding

Cellular components

• axon
• axon terminus
• cell surface
• cytoplasm
• plasma membrane
• receptor complex
• stress fiber

Protein domainsUniProt · Pfam · InterPro

• Kringle
• Protein kinase domain
• Serine-threonine/tyrosine-protein kinase, catalytic domain
• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Tyrosine-protein kinase, active site
• Protein kinase-like domain superfamily
• Immunoglobulin I-set
• Immunoglobulin-like fold
• Kringle-like fold
• Tyrosine-protein kinase, receptor ROR
• Kringle, conserved site
• Frizzled domain
• Immunoglobulin-like domain superfamily
• Frizzled cysteine-rich domain superfamily
• Kringle superfamily
• Receptor Tyrosine Kinase
• Kringle domain
• Fz domain
• Immunoglobulin I-set domain
• Protein tyrosine and serine/threonine kinase

KeywordsUniProt

• ATP-binding
• Cell projection
• Deafness
• Disulfide bond
• Glycoprotein
• Immunoglobulin domain
• Kinase
• Kringle
• Membrane
• Non-syndromic deafness
• Nucleotide-binding
• Phosphoprotein
• Receptor
• Signal
• Transferase
• Transmembrane
• Transmembrane helix
• Wnt signaling pathway

InteractionsUniProt · HPA

Protein binding partners of ROR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ERBB2
• IGFBP5