Seroatlas · Human Serome Atlas

AXL

Tyrosine-protein kinase receptor UFO

Also known as: ARK, JTK11, Tyro7, UFO, UFO_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P30530
Gene
AXL
Ensembl
ENSG00000167601
Chromosome
19
Canonical length
894 aa
Protein class
Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins
Subcellular location
Vesicles,Plasma membrane,Actin filaments

OverviewNCBI Gene

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021]

Canonical amino-acid sequenceUniProt

894 residues, UniProt reviewed canonical sequence.

>P30530|AXL
     1  MAWRCPRMGR VPLAWCLALC GWACMAPRGT QAEESPFVGN PGNITGARGL TGTLRCQLQV
    61  QGEPPEVHWL RDGQILELAD STQTQVPLGE DEQDDWIVVS QLRITSLQLS DTGQYQCLVF
   121  LGHQTFVSQP GYVGLEGLPY FLEEPEDRTV AANTPFNLSC QAQGPPEPVD LLWLQDAVPL
   181  ATAPGHGPQR SLHVPGLNKT SSFSCEAHNA KGVTTSRTAT ITVLPQQPRN LHLVSRQPTE
   241  LEVAWTPGLS GIYPLTHCTL QAVLSDDGMG IQAGEPDPPE EPLTSQASVP PHQLRLGSLH
   301  PHTPYHIRVA CTSSQGPSSW THWLPVETPE GVPLGPPENI SATRNGSQAF VHWQEPRAPL
   361  QGTLLGYRLA YQGQDTPEVL MDIGLRQEVT LELQGDGSVS NLTVCVAAYT AAGDGPWSLP
   421  VPLEAWRPGQ AQPVHQLVKE PSTPAFSWPW WYVLLGAVVA AACVLILALF LVHRRKKETR
   481  YGEVFEPTVE RGELVVRYRV RKSYSRRTTE ATLNSLGISE ELKEKLRDVM VDRHKVALGK
   541  TLGEGEFGAV MEGQLNQDDS ILKVAVKTMK IAICTRSELE DFLSEAVCMK EFDHPNVMRL
   601  IGVCFQGSER ESFPAPVVIL PFMKHGDLHS FLLYSRLGDQ PVYLPTQMLV KFMADIASGM
   661  EYLSTKRFIH RDLAARNCML NENMSVCVAD FGLSKKIYNG DYYRQGRIAK MPVKWIAIES
   721  LADRVYTSKS DVWSFGVTMW EIATRGQTPY PGVENSEIYD YLRQGNRLKQ PADCLDGLYA
   781  LMSRCWELNP QDRPSFTELR EDLENTLKAL PPAQEPDEIL YVNMDEGGGY PEPPGAAGGA
   841  DPPTQPDPKD SCSCLTAAEV HPAGRYVLCP STTPSPAQPA DRGSPAAPGQ EDGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AXL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
72 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 72 nTPM
  • adipose tissue: 42 nTPM
  • colon: 40 nTPM
  • spleen: 35 nTPM
  • smooth muscle: 35 nTPM
  • placenta: 32 nTPM

Single-cell type

  • kupffer cells: 591 nCPM
  • vascular smooth muscle cells: 392 nCPM
  • pericytes: 324 nCPM
  • decidual stromal cells: 294 nCPM
  • hepatic stellate cells: 245 nCPM
  • fibroblasts: 236 nCPM

Immune cell

  • plasmacytoid DC: 26 nTPM
  • NK-cell: 11 nTPM
  • myeloid DC: 6 nTPM
  • basophil: 1.4 nTPM
  • classical monocyte: 0.3 nTPM
  • intermediate monocyte: 0.3 nTPM

Brain region

  • medulla oblongata: 51 nTPM
  • thalamus: 44 nTPM
  • basal ganglia: 41 nTPM
  • white matter: 40 nTPM
  • spinal cord: 38 nTPM
  • cerebral cortex: 38 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AXL.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 302 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.01
gnomAD missense Z
1.44
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AXL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AXL as an antibody target. Whether an autoantibody or antibody against AXL could matter depends on whether native AXL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AXL is annotated at the cell surface, where native AXL is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AXL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AXL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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