LTK

Protein identityUniProt · HPA

UniProt accession

P29376

Gene

LTK

Ensembl

ENSG00000062524

Chromosome

15

Canonical length

864 aa

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Vesicles

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

864 residues, UniProt reviewed canonical sequence.

>P29376|LTK
     1  MGCWGQLLVW FGAAGAILCS SPGSQETFLR SSPLPLASPS PRDPKVSAPP SILEPASPLN
    61  SPGTEGSWLF STCGASGRHG PTQTQCDGAY AGTSVVVTVG AAGQLRGVQL WRVPGPGQYL
   121  ISAYGAAGGK GAKNHLSRAH GVFVSAIFSL GLGESLYILV GQQGEDACPG GSPESQLVCL
   181  GESRAVEEHA AMDGSEGVPG SRRWAGGGGG GGGATYVFRV RAGELEPLLV AAGGGGRAYL
   241  RPRDRGRTQA SPEKLENRSE APGSGGRGGA AGGGGGWTSR APSPQAGRSL QEGAEGGQGC
   301  SEAWATLGWA AAGGFGGGGG ACTAGGGGGG YRGGDASETD NLWADGEDGV SFIHPSSELF
   361  LQPLAVTENH GEVEIRRHLN CSHCPLRDCQ WQAELQLAEC LCPEGMELAV DNVTCMDLHK
   421  PPGPLVLMVA VVATSTLSLL MVCGVLILVK QKKWQGLQEM RLPSPELELS KLRTSAIRTA
   481  PNPYYCQVGL GPAQSWPLPP GVTEVSPANV TLLRALGHGA FGEVYEGLVI GLPGDSSPLQ
   541  VAIKTLPELC SPQDELDFLM EALIISKFRH QNIVRCVGLS LRATPRLILL ELMSGGDMKS
   601  FLRHSRPHLG QPSPLVMRDL LQLAQDIAQG CHYLEENHFI HRDIAARNCL LSCAGPSRVA
   661  KIGDFGMARD IYRASYYRRG DRALLPVKWM PPEAFLEGIF TSKTDSWSFG VLLWEIFSLG
   721  YMPYPGRTNQ EVLDFVVGGG RMDPPRGCPG PVYRIMTQCW QHEPELRPSF ASILERLQYC
   781  TQDPDVLNSL LPMELGPTPE EEGTSGLGNR SLECLRPPQP QELSPEKLKS WGGSPLGPWL
   841  SSGLKPLKSR GLQPQNLWNP TYRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LTK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

14 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.22

gnomAD pLI

0

gnomAD missense Z

-0.49

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell population proliferation
• cell surface receptor protein tyrosine kinase signaling pathway
• cellular response to retinoic acid
• negative regulation of apoptotic process
• peptidyl-tyrosine autophosphorylation
• positive regulation of cardiac muscle cell apoptotic process
• positive regulation of neuron projection development
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• protein phosphorylation
• regulation of cell population proliferation
• regulation of neuron differentiation
• signal transduction

Molecular functions

• ATP binding
• protein kinase activity
• protein tyrosine kinase activity
• receptor signaling protein tyrosine kinase activator activity
• transmembrane receptor protein tyrosine kinase activity

Cellular components

• membrane
• plasma membrane
• receptor complex

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Serine-threonine/tyrosine-protein kinase, catalytic domain
• Tyrosine-protein kinase, receptor class II, conserved site
• Tyrosine-protein kinase, active site
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• Tyrosine-protein kinase, catalytic domain
• Receptor Tyrosine Kinase
• ALK/LTK-like, glycine-rich domain
• Protein tyrosine and serine/threonine kinase
• ALK/LTK, Glycine-rich domain

KeywordsUniProt

• ATP-binding
• Cell membrane
• Disulfide bond
• Glycoprotein
• Kinase
• Membrane
• Nucleotide-binding
• Phosphoprotein
• Receptor
• Signal
• Systemic lupus erythematosus
• Transferase
• Transmembrane
• Transmembrane helix
• Tyrosine-protein kinase

InteractionsUniProt · HPA

Protein binding partners of LTK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EPHA2