TYRO3

Protein identityUniProt · HPA

UniProt accession

Q06418

Gene

TYRO3

Ensembl

ENSG00000092445

Chromosome

15

Canonical length

890 aa

Protein class

Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

890 residues, UniProt reviewed canonical sequence.

>Q06418|TYRO3
     1  MALRRSMGRP GLPPLPLPPP PRLGLLLAAL ASLLLPESAA AGLKLMGAPV KLTVSQGQPV
    61  KLNCSVEGME EPDIQWVKDG AVVQNLDQLY IPVSEQHWIG FLSLKSVERS DAGRYWCQVE
   121  DGGETEISQP VWLTVEGVPF FTVEPKDLAV PPNAPFQLSC EAVGPPEPVT IVWWRGTTKI
   181  GGPAPSPSVL NVTGVTQSTM FSCEAHNLKG LASSRTATVH LQALPAAPFN ITVTKLSSSN
   241  ASVAWMPGAD GRALLQSCTV QVTQAPGGWE VLAVVVPVPP FTCLLRDLVP ATNYSLRVRC
   301  ANALGPSPYA DWVPFQTKGL APASAPQNLH AIRTDSGLIL EWEEVIPEAP LEGPLGPYKL
   361  SWVQDNGTQD ELTVEGTRAN LTGWDPQKDL IVRVCVSNAV GCGPWSQPLV VSSHDRAGQQ
   421  GPPHSRTSWV PVVLGVLTAL VTAAALALIL LRKRRKETRF GQAFDSVMAR GEPAVHFRAA
   481  RSFNRERPER IEATLDSLGI SDELKEKLED VLIPEQQFTL GRMLGKGEFG SVREAQLKQE
   541  DGSFVKVAVK MLKADIIASS DIEEFLREAA CMKEFDHPHV AKLVGVSLRS RAKGRLPIPM
   601  VILPFMKHGD LHAFLLASRI GENPFNLPLQ TLIRFMVDIA CGMEYLSSRN FIHRDLAARN
   661  CMLAEDMTVC VADFGLSRKI YSGDYYRQGC ASKLPVKWLA LESLADNLYT VQSDVWAFGV
   721  TMWEIMTRGQ TPYAGIENAE IYNYLIGGNR LKQPPECMED VYDLMYQCWS ADPKQRPSFT
   781  CLRMELENIL GQLSVLSASQ DPLYINIERA EEPTAGGSLE LPGRDQPYSG AGDGSGMGAV
   841  GGTPSDCRYI LTPGGLAEQP GQAEHQPESP LNETQRLLLL QQGLLPHSSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TYRO3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

44 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.74

gnomAD pLI

0

gnomAD missense Z

1.57

DepMap mean gene effect

-0.29

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic cell clearance
• cell adhesion
• cell migration
• cell surface receptor protein tyrosine kinase signaling pathway
• establishment of localization in cell
• forebrain cell migration
• natural killer cell differentiation
• negative regulation of inflammatory response
• negative regulation of innate immune response
• negative regulation of lymphocyte activation
• negative regulation of neuron apoptotic process
• negative regulation of toll-like receptor signaling pathway
• nervous system development
• neuron apoptotic process
• neuron cellular homeostasis
• neuron migration
• neuropeptide signaling pathway
• ovulation cycle
• phagocytosis
• phosphatidylinositol 3-kinase/protein kinase B signal transduction
• platelet activation
• platelet aggregation
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• positive regulation of viral life cycle
• secretion by cell
• signal transduction
• spermatogenesis
• substrate adhesion-dependent cell spreading
• vagina development

Molecular functions

• ATP binding
• phosphatidylinositol 3-kinase binding
• protein tyrosine kinase activity
• transmembrane receptor protein tyrosine kinase activity
• virus receptor activity

Cellular components

• cell surface
• endoplasmic reticulum membrane
• nuclear envelope
• nucleus
• plasma membrane
• receptor complex

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Serine-threonine/tyrosine-protein kinase, catalytic domain
• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Fibronectin type III
• Immunoglobulin-like domain
• Tyrosine-protein kinase, active site
• Protein kinase-like domain superfamily
• Immunoglobulin I-set
• Immunoglobulin-like fold
• Protein kinase, ATP binding site
• Tyrosine-protein kinase, catalytic domain
• Fibronectin type III superfamily
• Immunoglobulin-like domain superfamily
• Receptor Tyrosine Kinase
• Fibronectin type III domain
• Immunoglobulin I-set domain
• Protein tyrosine and serine/threonine kinase

KeywordsUniProt

• ATP-binding
• Cell adhesion
• Cell membrane
• Disulfide bond
• Glycoprotein
• Host cell receptor for virus entry
• Host-virus interaction
• Immunoglobulin domain
• Kinase
• Membrane
• Nucleotide-binding
• Phosphoprotein
• Receptor
• Repeat
• Signal
• Transferase
• Transmembrane
• Transmembrane helix
• Tyrosine-protein kinase

InteractionsUniProt · HPA

Protein binding partners of TYRO3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PIK3R1
• TULP1
• GRB2