Seroatlas · Human Serome Atlas

STYK1

Tyrosine-protein kinase STYK1

Also known as: DKFZp761P1010, NOK, STYK1_HUMAN, SuRTK106

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6J9G0
Gene: STYK1
Ensembl: ENSG00000060140
Chromosome: 12
Canonical length: 422 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>Q6J9G0|STYK1
     1  MGMTRMLLEC SLSDKLCVIQ EKQYEVIIVP TLLVTIFLIL LGVILWLFIR EQRTQQQRSG
    61  PQGIAPVPPP RDLSWEAGHG GNVALPLKET SVENFLGATT PALAKLQVPR EQLSEVLEQI
   121  CSGSCGPIFR ANMNTGDPSK PKSVILKALK EPAGLHEVQD FLGRIQFHQY LGKHKNLVQL
   181  EGCCTEKLPL YMVLEDVAQG DLLSFLWTCR RDVMTMDGLL YDLTEKQVYH IGKQVLLALE
   241  FLQEKHLFHG DVAARNILMQ SDLTAKLCGL GLAYEVYTRG AISSTQTIPL KWLAPERLLL
   301  RPASIRADVW SFGILLYEMV TLGAPPYPEV PPTSILEHLQ RRKIMKRPSS CTHTMYSIMK
   361  SCWRWREADR PSPRELRLRL EAAIKTADDE AVLQVPELVV PELYAAVAGI RVESLFYNYS
   421  ML

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STYK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

stomach: 17 nTPM
rectum: 16 nTPM
colon: 15 nTPM
prostate: 11 nTPM
small intestine: 11 nTPM
cerebral cortex: 7.7 nTPM

Single-cell type

foveolar cells: 114 nCPM
urothelial cells: 102 nCPM
prostatic glandular cells: 91 nCPM
esophageal apical cells: 77 nCPM
prostatic hillock cells: 68 nCPM
prostatic club cells: 65 nCPM

Immune cell

NK-cell: 13 nTPM
gdT-cell: 1.7 nTPM
memory CD8 T-cell: 1.2 nTPM
naive CD8 T-cell: 1 nTPM
total PBMC: 0.3 nTPM
neutrophil: 0.1 nTPM

Brain region

cerebral cortex: 24 nTPM
basal ganglia: 19 nTPM
white matter: 14 nTPM
amygdala: 12 nTPM
pons: 10 nTPM
hippocampal formation: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 0.03
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STYK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HSP90AB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STYK1 as an antibody target. Whether an autoantibody or antibody against STYK1 could matter depends on whether native STYK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STYK1 is annotated at the cell surface, where native STYK1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label STYK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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