Seroatlas · Human Serome Atlas

NTRK2

BDNF/NT-3 growth factors receptor

Also known as: NTRK2_HUMAN, TRKB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16620
Gene
NTRK2
Ensembl
ENSG00000148053
Chromosome
9
Canonical length
822 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins, Transporters
Subcellular location
Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

822 residues, UniProt reviewed canonical sequence.

>Q16620|NTRK2
     1  MSSWIRWHGP AMARLWGFCW LVVGFWRAAF ACPTSCKCSA SRIWCSDPSP GIVAFPRLEP
    61  NSVDPENITE IFIANQKRLE IINEDDVEAY VGLRNLTIVD SGLKFVAHKA FLKNSNLQHI
   121  NFTRNKLTSL SRKHFRHLDL SELILVGNPF TCSCDIMWIK TLQEAKSSPD TQDLYCLNES
   181  SKNIPLANLQ IPNCGLPSAN LAAPNLTVEE GKSITLSCSV AGDPVPNMYW DVGNLVSKHM
   241  NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH
   301  WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYT
   361  LIAKNEYGKD EKQISAHFMG WPGIDDGANP NYPDVIYEDY GTAANDIGDT TNRSNEIPST
   421  DVTDKTGREH LSVYAVVVIA SVVGFCLLVM LFLLKLARHS KFGMKGPASV ISNDDDSASP
   481  LHHISNGSNT PSSSEGGPDA VIIGMTKIPV IENPQYFGIT NSQLKPDTFV QHIKRHNIVL
   541  KRELGEGAFG KVFLAECYNL CPEQDKILVA VKTLKDASDN ARKDFHREAE LLTNLQHEHI
   601  VKFYGVCVEG DPLIMVFEYM KHGDLNKFLR AHGPDAVLMA EGNPPTELTQ SQMLHIAQQI
   661  AAGMVYLASQ HFVHRDLATR NCLVGENLLV KIGDFGMSRD VYSTDYYRVG GHTMLPIRWM
   721  PPESIMYRKF TTESDVWSLG VVLWEIFTYG KQPWYQLSNN EVIECITQGR VLQRPRTCPQ
   781  EVYELMLGCW QREPHMRKNI KGIHTLLQNL AKASPVYLDI LG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NTRK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
233 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 233 nTPM
  • thyroid gland: 118 nTPM
  • choroid plexus: 88 nTPM
  • breast: 63 nTPM
  • amygdala: 48 nTPM
  • adipose tissue: 41 nTPM

Single-cell type

  • astrocytes: 2,373 nCPM
  • ependymal cells: 1,516 nCPM
  • oligodendrocyte progenitor cells: 781 nCPM
  • retinal horizontal cells: 751 nCPM
  • brain inhibitory neurons: 585 nCPM
  • breast lactating cells: 559 nCPM

Immune cell

  • basophil: 0.3 nTPM
  • neutrophil: 0.2 nTPM
  • NK-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • thalamus: 550 nTPM
  • hypothalamus: 529 nTPM
  • midbrain: 498 nTPM
  • amygdala: 453 nTPM
  • hippocampal formation: 393 nTPM
  • basal ganglia: 386 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NTRK2.

Disease | AllUniProt

Conditions NTRK2 is implicated in, by any mechanism.

  • Developmental and epileptic encephalopathy 58 (DEE58) MIM:617830
  • Obesity, hyperphagia, and developmental delay (OBHD) MIM:613886

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 855 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.11
gnomAD pLI
1
gnomAD missense Z
3.73
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NTRK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NTRK2 as an antibody target. Whether an autoantibody or antibody against NTRK2 could matter depends on whether native NTRK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NTRK2 is annotated at the cell surface, where native NTRK2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NTRK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NTRK2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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