Keratin, type I
IPR002957
Definition
Keratins are a well known group of intermediate filament proteins. Like actin filaments, keratins are flexible but provide a firm cell skeleton PMID:26902920. Unlike actin, however, no known keratins are associated with motor functions. Approximately 10 keratins form the basis of hair or claw, with a further 20 found in internal body cavity epithelia. They are also found at desmosomes and hemi-desmosomes (cell/cell and cell/matrix contacts respectively). Type I keratins are a group of acidic intermediate filament proteins that exist as chains of hetero-dimers with basic type II keratins. Each type I keratin consists of head-, rod- and tail-like structures, the rod being constructed from three linked coils: 1A, 1B and 2. Type I proteins are associated with a number of inherited developmental disorders, such as baldness, beading of hair, and skin blistering.
32 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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