Seroatlas · Human Serome Atlas

KRT28

Keratin, type I cytoskeletal 28

Also known as: K1C28_HUMAN, KRT25D

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z3Y7
Gene
KRT28
Ensembl
ENSG00000173908
Chromosome
17
Canonical length
464 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>Q7Z3Y7|KRT28
     1  MSLQFSNGSR HVCLRSGAGS VRPLNGGAGF AGSSACGGSV AGSEFSCALG GGLGSVPGGS
    61  HAGGALGNAA CIGFAGSEGG LLSGNEKVTM QNLNDRLASY LDNVRALEEA NAELERKIKG
   121  WYEKYGPGSC RGLDHDYSRY HLTIEDLKNK IISSTTTNAN VILQIDNARL AADDFRLKYE
   181  NELTLHQNVE ADINGLRRVL DELTLCRTDQ ELQYESLSEE MTYLKKNHEE EMKALQCAAG
   241  GNVNVEMNAA PGVDLAVLLN NMRAEYEALA EQNRKDAEAW FNEKSASLQQ QISHDSGAAT
   301  FARSQLTEMR RTLQTLEIQL QSLMATKHSL ECSLTETESN YCTQLAQIQA QIGALEEQLH
   361  QVRTETEGQK LEYEHLLDVK VHLEKEIETY CRLIDGDGNS CSKSKGFGSG SPGNSSKDLS
   421  KTTLVKTVVE ELDQRGKVLS SRIHSIEEKT SKMTNGKTEQ RVPF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • skin: 11 nTPM
  • breast: 0.7 nTPM
  • adipose tissue: 0.3 nTPM
  • testis: 0.2 nTPM
  • salivary gland: 0.1 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • retinal ganglion cells: 3.9 nCPM
  • undifferentiated spermatogonia: 2.3 nCPM
  • late spermatids: 0.7 nCPM
  • leydig cells: 0.5 nCPM
  • late primary spermatocytes: 0.2 nCPM
  • peritubular myoid cells: 0.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.14
gnomAD pLI
0
gnomAD missense Z
0.11
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT28 as an antibody target. Whether an autoantibody or antibody against KRT28 could matter depends on whether native KRT28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT28 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRT28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRT28. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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