Seroatlas · Human Serome Atlas

KRT39

Keratin, type I cytoskeletal 39

Also known as: K1C39_HUMAN, KA35

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6A163
Gene
KRT39
Ensembl
ENSG00000196859
Chromosome
17
Canonical length
491 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mid piece,Principal piece,Annulus

OverviewNCBI Gene

This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

Canonical amino-acid sequenceUniProt

491 residues, UniProt reviewed canonical sequence.

>Q6A163|KRT39
     1  MDTKGCTTTN SPSTPCQNCS RITNVSTISS NNGCHPGGLT VNNCQPAGHV LRIPWDQGCQ
    61  PTPRFCRKPI YLMNNFNARF SLDDCSWYGE GINSNEKETM QILNERLANY LQKVRMLERE
   121  NAELESKIQE ESNKELPVLC PDYLSYYTTI EELQQKILCT KAENSRLVSQ IDNTKLTADD
   181  LRAKYEAEVS LRQLVESDAN GLKQILNVLT LGKADLEAQV QSLKEELLCL KNNHKEEINS
   241  LQCQLGERLD IEVTAAPSAD LNQVLQEMRC QYEPIMETNR KDVEQWFNTQ IEELNQQVVT
   301  SSQQQQCCQK EIIELRRSVN TLEVELQAQH RMRDSQECIL TETEARYTAL LTQIQSLIDN
   361  LEAQLAEIRC ALERQNQEYE ILLDVKSRLE CEITTYRSLL ESSDGKRPCY PRATKCEPSP
   421  WTSCKSGAIE STAPACTSSS PCSLKEHCSA CGPLSRILVK ICTITKEIKD GKVISSYEHV
   481  QPCFIIRPAK V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
4.8 nTPM

Expression across tissuesHPA

Tissue

  • skin: 4.8 nTPM
  • retina: 0.9 nTPM
  • pituitary gland: 0.1 nTPM
  • salivary gland: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • brain inhibitory neurons: 0.1 nCPM
  • renal connecting tubule cells: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.2 nTPM
  • hypothalamus: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • pons: 0.1 nTPM
  • thalamus: 0.1 nTPM
  • white matter: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
0.16
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT39 as an antibody target. Whether an autoantibody or antibody against KRT39 could matter depends on whether native KRT39 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT39 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRT39 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRT39. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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