KRT33A
Keratin, type I cuticular Ha3-I
Also known as: Ha-3I, Krt1-3, KRTHA3A, KT33A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O76009
- Gene
- KRT33A
- Ensembl
- ENSG00000006059
- Chromosome
- 17
- Canonical length
- 404 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol,Equatorial segment,Mid piece,Principal piece,End piece
OverviewNCBI Gene
This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. [provided by RefSeq, May 2012]
Canonical amino-acid sequenceUniProt
404 residues, UniProt reviewed canonical sequence.
>O76009|KRT33A
1 MSYSCGLPSL SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VSNCNWFCEG SFNGSEKETM
61 QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLVC ASYQSYFKTI EELQQKILCS
121 KSENARLVVQ IDNAKLASDD FRTKYETELS LRQLVESDIN GLRRILDELT LCRSDLEAQV
181 ESLKEELLCL KQNHEQEVNT LRCQLGDRLN VEVDAAPTVD LNQVLNETRS QYEALVETNR
241 REVEQWFATQ TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL
301 TESEARYSSQ LSQVQRLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL
361 ESEDCKLPSN PCATTNACDK STGPCISNPC GLRARCGPCN TFGYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against KRT33A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 43 nTPM
Expression across tissuesHPA
Tissue
- skin: 43 nTPM
- testis: 2.4 nTPM
- salivary gland: 1.3 nTPM
- esophagus: 0.9 nTPM
- adipose tissue: 0.5 nTPM
- vagina: 0.2 nTPM
Single-cell type
- late spermatids: 1.7 nCPM
- early spermatids: 1.2 nCPM
- t-cells: 0.2 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.69
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.02
- DepMap mean gene effect
- -0.28
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KRT33A as an antibody target. Whether an autoantibody or antibody against KRT33A could matter depends on whether native KRT33A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KRT33A is annotated as secreted, so native KRT33A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label KRT33A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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