Seroatlas · Human Serome Atlas

KRT34

Keratin, type I cuticular Ha4

Also known as: Ha-4, KRT34_HUMAN, KRTHA4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O76011
Gene
KRT34
Ensembl
ENSG00000131737
Chromosome
17
Canonical length
394 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol,Equatorial segment,Mid piece,Principal piece,End piece

OverviewNCBI Gene

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

394 residues, UniProt reviewed canonical sequence.

>O76011|KRT34
     1  MSYSCCLPSL GCRTSCSSRP CVPPSCHGYT LPGACNIPAN VSNCNWFCEG SFNGSEKETM
    61  QFLNDRLASY LEKVRQLERD NAELEKLIQE RSQQQEPLLC PSYQSYFKTI EELQQKILCA
   121  KAENARLVVN IDNAKLASDD FRSKYQTEQS LRLLVESDIN SIRRILDELT LCKSDLESQV
   181  ESLREELICL KKNHEEEVNT LRSQLGDRLN VEVDTAPTVD LNQVLNETRS QYEALVEINR
   241  REVEQWFATQ TEELNKQVVS SSEQLQSCQA EIIELRRTVN ALEIELQAQH NLRDSLENTL
   301  TESEAHYSSQ LSQVQSLITN VESQLAEIRC DLERQNQEYQ VLLDVRARLE CEINTYRSLL
   361  ESEDCKLPCN PCATTNASGN SCGPCGTSQK GCCN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • skin: 65 nTPM
  • cervix: 2.8 nTPM
  • vagina: 1.9 nTPM
  • salivary gland: 1.4 nTPM
  • testis: 0.8 nTPM
  • cerebellum: 0.5 nTPM

Single-cell type

  • late spermatids: 1 nCPM
  • early spermatids: 0.3 nCPM
  • endometrial luminal cells: 0.2 nCPM
  • brain excitatory neurons: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
-1.34
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRT34 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT34 as an antibody target. Whether an autoantibody or antibody against KRT34 could matter depends on whether native KRT34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT34 is annotated as secreted, so native KRT34 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label KRT34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRT34. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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