Seroatlas · Human Serome Atlas

KRT37

Keratin, type I cuticular Ha7

Also known as: KRT37_HUMAN, KRTHA7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O76014
Gene: KRT37
Ensembl: ENSG00000108417
Chromosome: 17
Canonical length: 449 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

449 residues, UniProt reviewed canonical sequence.

>O76014|KRT37
     1  MTSFYSTSSC PLGCTMAPGA RNVFVSPIDV GCQPVAEANA ASMCLLANVA HANRVRVGST
    61  PLGRPSLCLP PTSHTACPLP GTCHIPGNIG ICGAYGKNTL NGHEKETMKF LNDRLANYLE
   121  KVRQLEQENA ELETTLLERS KCHESTVCPD YQSYFRTIEE LQQKILCSKA ENARLIVQID
   181  NAKLAADDFR IKLESERSLH QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS
   241  NHEQEVKILR SQLGEKFRIE LDIEPTIDLN RVLGEMRAQY EAMVETNHQD VEQWFQAQSE
   301  GISLQAMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE AEDRYGTELA
   361  QMQSLISNLE EQLSEIRADL ERQNQEYQVL LDVKARLENE IATYRNLLES EDCKLPCNPC
   421  STPASCTSCP SCGPVTGGSP SGHGASMGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 6.2 nTPM

Expression across tissuesHPA

Tissue

skin: 6.2 nTPM
cervix: 0.3 nTPM
thymus: 0.1 nTPM
vagina: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late spermatids: 0.4 nCPM
undifferentiated spermatogonia: 0.2 nCPM
decidual stromal cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.2 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: -0.36
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT37 as an antibody target. Whether an autoantibody or antibody against KRT37 could matter depends on whether native KRT37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT37 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRT37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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