Seroatlas · Human Serome Atlas

KRT24

Keratin, type I cytoskeletal 24

Also known as: FLJ20261, K1C24_HUMAN, MGC138169, MGC138173

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2M2I5
Gene: KRT24
Ensembl: ENSG00000167916
Chromosome: 17
Canonical length: 525 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Intermediate filaments,Cytosol

OverviewNCBI Gene

This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

525 residues, UniProt reviewed canonical sequence.

>Q2M2I5|KRT24
     1  MSCSSRASSS RAGGSSSARV SAGGSSFSSG SRCGLGGSSA QGFRGGASSC SLSGGSSGAF
    61  GGSFGGGFGS CSVGGGFGGA SGSGTGFGGG SSFGGVSGFG RGSGFCGSSR FSSGATGGFY
   121  SYGGGMGGGV GDGGLFSGGE KQTMQNLNDR LANYLDKVRA LEEANTDLEN KIKEWYDKYG
   181  PGSGDGGSGR DYSKYYSIIE DLRNQIIAAT VENAGIILHI DNARLAADDF RLKYENELCL
   241  RQSVEADING LRKVLDDLTM TRSDLEMQIE SFTEELAYLR KNHEEEMKNM QGSSGGEVTV
   301  EMNAAPGTDL TKLLNDMRAQ YEELAEQNRR EAEERFNKQS ASLQAQISTD AGAATSAKNE
   361  ITELKRTLQA LEIELQSQLA MKSSLEGTLA DTEAGYVAQL SEIQTQISAL EEEICQIWGE
   421  TKCQNAEYKQ LLDIKTRLEV EIETYRRLLD GEGGGSSFAE FGGRNSGSVN MGSRDLVSGD
   481  SRSGSCSGQG RDSSKTRVTK TIVEELVDGK VVSSQVSSIS EVKVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 168 nTPM

Expression across tissuesHPA

Tissue

esophagus: 168 nTPM
tonsil: 72 nTPM
cervix: 44 nTPM
epididymis: 16 nTPM
vagina: 13 nTPM
colon: 7.5 nTPM

Single-cell type

esophageal apical cells: 940 nCPM
ocular epithelial cells: 386 nCPM
epididymal principal cells: 78 nCPM
esophageal suprabasal cells: 64 nCPM
cytotrophoblasts: 7.5 nCPM
suprabasal keratinocytes: 7.5 nCPM

Immune cell

T-reg: 0.4 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 0.2 nTPM
hypothalamus: 0.1 nTPM
midbrain: 0.1 nTPM
pons: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: -0.07
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of skin epidermis

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRT24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KRT4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT24 as an antibody target. Whether an autoantibody or antibody against KRT24 could matter depends on whether native KRT24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRT24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...