KRT10

Protein identityUniProt · HPA

UniProt accession

P13645

Gene

KRT10

Ensembl

ENSG00000186395

Chromosome

17

Canonical length

584 aa

Protein class

Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted in other tissues

OverviewNCBI Gene

This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

584 residues, UniProt reviewed canonical sequence.

>P13645|KRT10
     1  MSVRYSSSKH YSSSRSGGGG GGGGCGGGGG VSSLRISSSK GSLGGGFSSG GFSGGSFSRG
    61  SSGGGCFGGS SGGYGGLGGF GGGSFRGSYG SSSFGGSYGG IFGGGSFGGG SFGGGSFGGG
   121  GFGGGGFGGG FGGGFGGDGG LLSGNEKVTM QNLNDRLASY LDKVRALEES NYELEGKIKE
   181  WYEKHGNSHQ GEPRDYSKYY KTIDDLKNQI LNLTTDNANI LLQIDNARLA ADDFRLKYEN
   241  EVALRQSVEA DINGLRRVLD ELTLTKADLE MQIESLTEEL AYLKKNHEEE MKDLRNVSTG
   301  DVNVEMNAAP GVDLTQLLNN MRSQYEQLAE QNRKDAEAWF NEKSKELTTE IDNNIEQISS
   361  YKSEITELRR NVQALEIELQ SQLALKQSLE ASLAETEGRY CVQLSQIQAQ ISALEEQLQQ
   421  IRAETECQNT EYQQLLDIKI RLENEIQTYR SLLEGEGSSG GGGRGGGSFG GGYGGGSSGG
   481  GSSGGGHGGG HGGSSGGGYG GGSSGGGSSG GGYGGGSSSG GHGGSSSGGY GGGSSGGGGG
   541  GYGGGSSGGG SSSGGGYGGG SSSGGHKSSS SGSVGESSSK GPRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.61

Highest tissue expression

14,581 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KRT10.

Disease | AllUniProt

Conditions KRT10 is implicated in, by any mechanism.

• Epidermolytic hyperkeratosis 2A (EHK2A) MIM:620150
• Epidermolytic hyperkeratosis 2B, autosomal recessive (EHK2B) MIM:620707
• Ichthyosis, annular epidermolytic, 1 (AEI1) MIM:607602
• Ichthyosis with confetti (IWC) MIM:609165
• Ichthyosis histrix, Lambert type (IHL) MIM:146600

Disease | GeneticClinVar

41 pathogenic / likely-pathogenic of 287 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Epidermolytic hyperkeratosis 2A, autosomal dominant
• Congenital reticular ichthyosiform erythroderma
• Epidermolytic hyperkeratosis 2B, autosomal recessive
• Epidermolytic hyperkeratosis 1
• KRT10-related disorder

Disease | ImmuneIEDB

Conditions an epitope on KRT10 was assayed in.

• psoriasis T cell

ReferencesPubMed · IEDB

Publications for KRT10 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.62

gnomAD pLI

0

gnomAD missense Z

0.25

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cornification
• intermediate filament organization
• keratinocyte differentiation
• morphogenesis of an epithelium
• positive regulation of epidermis development
• protein heterotetramerization

Molecular functions

• protein heterodimerization activity
• structural constituent of skin epidermis

Cellular components

• cell surface
• cornified envelope
• cytoplasm
• cytoskeleton
• cytosol
• extracellular exosome
• extracellular space
• intermediate filament
• keratin filament
• membrane
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Keratin, type I
• Intermediate filament protein, conserved site
• Intermediate filament, rod domain
• Intermediate filament protein

KeywordsUniProt

• Coiled coil
• Cytoplasm
• Disulfide bond
• Ichthyosis
• Intermediate filament
• Keratin
• Phosphoprotein
• Secreted

InteractionsUniProt · HPA

Protein binding partners of KRT10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PLEC
• KRT1