Seroatlas · Human Serome Atlas

KRT222

Keratin-like protein KRT222

Also known as: KA21, KRT222P, KT222_HUMAN, MGC45562

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N1A0
Gene: KRT222
Ensembl: ENSG00000213424
Chromosome: 17
Canonical length: 295 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Lipid droplets

OverviewNCBI Gene

Predicted to enable structural molecule activity. Predicted to be located in intermediate filament. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

295 residues, UniProt reviewed canonical sequence.

>Q8N1A0|KRT222
     1  MELSQLLNEI RANYEKILTR NQIETVLSTR IQLEEDISKK MDKDEEALKA AQAELKEARR
    61  QWHHLQVEIE SLHAVERGLE NSLHASEQHY QMQLQDLETV IEGLEKELQE VRRGIEKQLQ
   121  EHEMLLNTKM RLEQEIATYR HLLEKEEIRY YGCIQGGKKD KKPTTSRVGF VLPSAIINEI
   181  SFTTKVPQKY ENENVETVTK QAILNGSIVK ESTEAHGTIQ TEKVDEVIKE WEGSFFKDNP
   241  RLRKKSVSLR FDLHLAATDE GCLETKQDNL PDIEVRLIMR RSCSIPSIKP PSTAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT222 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 11 nTPM
cerebellum: 11 nTPM
basal ganglia: 8.5 nTPM
retina: 7.4 nTPM
hypothalamus: 6.1 nTPM
amygdala: 5.9 nTPM

Single-cell type

epididymal basal cells: 4.5 nCPM
retinal bipolar cells: 2.6 nCPM
medullary thymic epithelial cells: 2.4 nCPM
epididymal principal cells: 2.3 nCPM
müller glia: 2 nCPM
ocular epithelial cells: 1.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 21 nTPM
cerebellum: 15 nTPM
white matter: 13 nTPM
basal ganglia: 12 nTPM
hypothalamus: 11 nTPM
thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

structural molecule activity

Cellular components

intermediate filament

Protein domainsUniProt · Pfam · InterPro

Keratin, type I
Intermediate filament protein, conserved site
Intermediate filament, rod domain
Intermediate filament protein
Intermediate Filament Keratin-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT222 as an antibody target. Whether an autoantibody or antibody against KRT222 could matter depends on whether native KRT222 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT222 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRT222 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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