Seroatlas · Human Serome Atlas

KRT35

Keratin, type I cuticular Ha5

Also known as: Ha-5, KRT35_HUMAN, KRTHA5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92764
Gene: KRT35
Ensembl: ENSG00000197079
Chromosome: 17
Canonical length: 455 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Intermediate filaments

OverviewNCBI Gene

The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

455 residues, UniProt reviewed canonical sequence.

>Q92764|KRT35
     1  MASKCLKAGF SSGSLKSPGG ASGGSTRVSA MYSSSSCKLP SLSPVARSFS ACSVGLGRSS
    61  YRATSCLPAL CLPAGGFATS YSGGGGWFGE GILTGNEKET MQSLNDRLAG YLEKVRQLEQ
   121  ENASLESRIR EWCEQQVPYM CPDYQSYFRT IEELQKKTLC SKAENARLVV EIDNAKLAAD
   181  DFRTKYETEV SLRQLVESDI NGLRRILDDL TLCKSDLEAQ VESLKEELLC LKKNHEEEVN
   241  SLRCQLGDRL NVEVDAAPPV DLNRVLEEMR CQYETLVENN RRDAEDWLDT QSEELNQQVV
   301  SSSEQLQSCQ AEIIELRRTV NALEIELQAQ HSMRDALEST LAETEARYSS QLAQMQCMIT
   361  NVEAQLAEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL LESEDSKLPC NPCAPDYSPS
   421  KSCLPCLPAA SCGPSAARTN CSPRPICVPC PGGRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT35 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

skin: 55 nTPM
adipose tissue: 1.7 nTPM
salivary gland: 0.8 nTPM
breast: 0.1 nTPM
spleen: 0.1 nTPM
adrenal gland: 0 nTPM

Single-cell type

epididymal clear cells: 4.1 nCPM
prostatic hillock cells: 0.6 nCPM
prostatic club cells: 0.5 nCPM
salivary ionocytes: 0.4 nCPM
urothelial cells: 0.4 nCPM
leydig cells: 0.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.7 nTPM
basal ganglia: 0.4 nTPM
cerebral cortex: 0.2 nTPM
thalamus: 0.2 nTPM
midbrain: 0.1 nTPM
spinal cord: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: -0.47
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of skin epidermis

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT35 as an antibody target. Whether an autoantibody or antibody against KRT35 could matter depends on whether native KRT35 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT35 is annotated as secreted, so native KRT35 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label KRT35 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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