Seroatlas · Human Serome Atlas

KRT26

Keratin, type I cytoskeletal 26

Also known as: K1C26_HUMAN, KRT25B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z3Y9
Gene: KRT26
Ensembl: ENSG00000186393
Chromosome: 17
Canonical length: 468 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the keratin superfamily. This keratin protein is a type I keratin that is specific for the inner root sheath of the hair follicle. This gene exists in a cluster with other keratin genes on chromosome 17q21. [provided by RefSeq, Jul 2009]

Canonical amino-acid sequenceUniProt

468 residues, UniProt reviewed canonical sequence.

>Q7Z3Y9|KRT26
     1  MSFRLSGGSR RICSRTGSGR LSGGGTGFVA GNVCVGSGAR SSFSCTLEGI SSGGSFCNSG
    61  GGLGSGACAG FLGNEHSLLS GNEKVTMQNL NDRLASYLDH VHALEEANAD LEQKIKGWYE
   121  KCEPGSSREH DHDYSRYFSV IEDLKRQIIS ATICNASIVL QNDNARLTAD DFRLKYENEL
   181  ALHHSVEADT SGLRRVLDEL TLCTTDLEIQ CETLSEELTY LKKSHEEEME VLQYTAGGNV
   241  NVEMNATPGV DLTVLLNNMR AEYEDLAEQN RKDAEAWFNE RSATLQQQIS DHEGAATAAR
   301  NELTELKRNL QTLEIELQSL MAVKHSYECS LAETEGNYCN QLQQIQDQIG VMEEQLQQIR
   361  TETEGQKLEY EQLLDVKIFL EKEIDIYCNL LDGEERKSKS TCYKSKGYRP VNSGNQAKDS
   421  TEETIVKTVV EELDQIGNLL SLRVHSVEEK SSKISNITVE QRVPSKAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 5.3 nTPM

Expression across tissuesHPA

Tissue

skin: 5.3 nTPM
choroid plexus: 0.9 nTPM
testis: 0.5 nTPM
adipose tissue: 0.1 nTPM
bone marrow: 0.1 nTPM
adrenal gland: 0 nTPM

Single-cell type

cone photoreceptor cells: 2.1 nCPM
undifferentiated spermatogonia: 1.2 nCPM
early spermatids: 0.4 nCPM
papillary tip epithelial cells: 0.4 nCPM
fibro-adipogenic progenitors: 0.3 nCPM
salivary myoepithelial cells: 0.3 nCPM

Immune cell

neutrophil: 3.4 nTPM
basophil: 2.1 nTPM
eosinophil: 0.1 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 1.3 nTPM
choroid plexus: 0.7 nTPM
medulla oblongata: 0.4 nTPM
midbrain: 0.4 nTPM
pons: 0.4 nTPM
cerebral cortex: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: -0.66
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of skin epidermis

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT26 as an antibody target. Whether an autoantibody or antibody against KRT26 could matter depends on whether native KRT26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRT26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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