Seroatlas · Human Serome Atlas

KRT36

Keratin, type I cuticular Ha6

Also known as: KRT36_HUMAN, KRTHA6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O76013
Gene: KRT36
Ensembl: ENSG00000126337
Chromosome: 17
Canonical length: 467 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

467 residues, UniProt reviewed canonical sequence.

>O76013|KRT36
     1  MATQTCTPTF STGSIKGLCG TAGGISRVSS IRSVGSCRVP SLAGAAGYIS SARSGLSGLG
    61  SCLPGSYLSS ECHTSGFVGS GGWFCEGSFN GSEKETMQFL NDRLANYLEK VRQLERENAE
   121  LESRIQEWYE FQIPYICPDY QSYFKTIEDF QQKILLTKSE NARLVLQIDN AKLAADDFRT
   181  KYETELSLRQ LVEADINGLR RILDELTLCK ADLEAQVESL KEELMCLKKN HEEEVSVLRC
   241  QLGDRLNVEV DAAPPVDLNK ILEDMRCQYE ALVENNRRDV EAWFNTQTEE LNQQVVSSSE
   301  QLQCCQTEII ELRRTVNALE IELQAQHSMR NSLESTLAET EARYSSQLAQ MQCLISNVEA
   361  QLSEIRCDLE RQNQEYQVLL DVKARLEGEI ATYRHLLEGE DCKLPPQPCA TACKPVIRVP
   421  SVPPVPCVPS VPCTPAPQVG TQIRTITEEI RDGKVISSRE HVQSRPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 3.1 nTPM

Expression across tissuesHPA

Tissue

thymus: 3.1 nTPM
skin: 1.7 nTPM
tonsil: 1.5 nTPM
ovary: 0.8 nTPM
vagina: 0.5 nTPM
esophagus: 0.4 nTPM

Single-cell type

oocytes: 364 nCPM
suprabasal keratinocytes: 171 nCPM
prostatic hillock cells: 10 nCPM
prostatic club cells: 7.6 nCPM
basal keratinocytes: 7 nCPM
myosatellite cells: 4.6 nCPM

Immune cell

classical monocyte: 0.4 nTPM
intermediate monocyte: 0.2 nTPM
myeloid DC: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hypothalamus: 0.5 nTPM
basal ganglia: 0.4 nTPM
thalamus: 0.2 nTPM
cerebral cortex: 0.1 nTPM
midbrain: 0.1 nTPM
spinal cord: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of skin epidermis

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT36 as an antibody target. Whether an autoantibody or antibody against KRT36 could matter depends on whether native KRT36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRT36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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