Keratin-associated protein
IPR002494
Definition
Keratin-associated proteins (KAPs) are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments [[cite:PMID:9524245], [cite:PMID:2250030]]. This entry also includes the high-sulfur and high-tyrosine keratins from sheep and goats. In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins, which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins PMID:14962103. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat PMID:9524245.
42 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (42 proteins: gene, accession, name)
- KRTAP1-1
- KRTAP1-3
- KRTAP1-4
- KRTAP1-5
- KRTAP10-1
- KRTAP10-10
- KRTAP10-11
- KRTAP10-12
- KRTAP10-2
- KRTAP10-3
- KRTAP10-4
- KRTAP10-5
- KRTAP10-6
- KRTAP10-7
- KRTAP10-8
- KRTAP10-9
- KRTAP12-1
- KRTAP16-1
- KRTAP2-1
- KRTAP2-2
- KRTAP2-3
- KRTAP2-4
- KRTAP29-1
- KRTAP4-1
- KRTAP4-11
- KRTAP4-12
- KRTAP4-16
- KRTAP4-2
- KRTAP4-3
- KRTAP4-4
- KRTAP4-5
- KRTAP4-6
- KRTAP4-7
- KRTAP4-8
- KRTAP4-9
- KRTAP5-11
- KRTAP9-2
- KRTAP9-3
- KRTAP9-4
- KRTAP9-6
- KRTAP9-7
- KRTAP9-9
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