Seroatlas · Human Serome Atlas

KRTAP4-6

Keratin-associated protein 4-6

Also known as: KAP4.15, KAP4.6, KRA46_HUMAN, KRTAP4-15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BYQ5
Gene
KRTAP4-6
Ensembl
ENSG00000198090
Chromosome
17
Canonical length
205 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q9BYQ5|KRTAP4-6
     1  MVSSCCGSVC SDQGCGLETC CRPSCCQTTC CRTTCCRPSC CVSSCCRPQC CQSVCCQPTC
    61  CRPSCCPSCC QTTCCRTTCC RPSCCVSSCC RPQCCQSVCC QPTCCRPSCS ISSCCRPSCC
   121  VSRCCRSQCC QSVCCQPTCC RPSCCISSCC RPSCCESSCC RPCCCRPCCC LRPVCGRVSC
   181  HTTCYRPTCV ISTCPRPLCC ASSCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTAP4-6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • skin: 31 nTPM
  • salivary gland: 0.4 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • endometrial secretory cells: 9.4 nCPM
  • epididymal basal cells: 2 nCPM
  • ocular epithelial cells: 1.3 nCPM
  • endometrial glandular cells: 0.4 nCPM
  • endometrial ciliated cells: 0.3 nCPM
  • breast secretory cells: 0.1 nCPM

Immune cell

  • naive B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.81
gnomAD pLI
0
gnomAD missense Z
-1.55
DepMap mean gene effect
-0.01
DepMap dependency class
selective

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTAP4-6 as an antibody target. Whether an autoantibody or antibody against KRTAP4-6 could matter depends on whether native KRTAP4-6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTAP4-6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTAP4-6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRTAP4-6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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