Seroatlas · Human Serome Atlas

KRTAP10-10

Keratin-associated protein 10-10

Also known as: KAP10.10, KAP18.10, KR10A_HUMAN, KRTAP18-10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P60014
Gene
KRTAP10-10
Ensembl
ENSG00000221859
Chromosome
21
Canonical length
251 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

251 residues, UniProt reviewed canonical sequence.

>P60014|KRTAP10-10
     1  MAASTMSICS SACTDSWRVV DCPESCCEPC CCAPAPSLTL VCTPVSCVSS PCCQTACEPS
    61  ACQSGYTSSC TTPCYQQSSC QPDCCTSSPC QQACCVPVCC VPVCCVPVCN KPVCFVPTCS
   121  ESSPSCCQQS SCQPTCCTSS PCQQACCVPV CSKSVCYVPV CSGASTSCCQ QSSCQPACCT
   181  ASCCRPSSSV SLLCHPVCKS TCCVPVPSCG ASASSCQPSC CRTASCVSLL CRPVCSRPAC
   241  YSLCSGQKSS C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTAP10-10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • skin: 17 nTPM
  • adipose tissue: 0.2 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • cardiomyocytes: 0.5 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 0.1 nTPM
  • choroid plexus: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • amygdala: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.53
gnomAD pLI
0
gnomAD missense Z
-1.23
DepMap mean gene effect
0.06
DepMap dependency class
none

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTAP10-10 as an antibody target. Whether an autoantibody or antibody against KRTAP10-10 could matter depends on whether native KRTAP10-10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTAP10-10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTAP10-10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRTAP10-10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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