Seroatlas · Human Serome Atlas

KRTAP16-1

Keratin-associated protein 16-1

Also known as: KAP16.1, KR161_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MUX0
Gene: KRTAP16-1
Ensembl: ENSG00000212657
Chromosome: 17
Canonical length: 517 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable structural molecule activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

517 residues, UniProt reviewed canonical sequence.

>A8MUX0|KRTAP16-1
     1  MSGSCSSRKC FSVPATSLCS TEVSCGGPIC LPSSCQSQTW QLVTCQDSCG SSSCGPQCRQ
    61  PSCPVSSCAQ PLCCDPVICE PSCSVSSGCQ PVCCEATTCE PSCSVSNCYQ PVCFEATICE
   121  PSCSVSNCCQ PVCFEATVCE PSCSVSSCAQ PVCCEPAICE PSCSVSSCCQ PVGSEATSCQ
   181  PVLCVPTSCQ PVLCKSSCCQ PVVCEPSCCS AVCTLPSSCQ PVVCEPSCCQ PVCPTPTCSV
   241  TSSCQAVCCD PSPCEPSCSE SSICQPATCV ALVCEPVCLR PVCCVQSSCE PPSVPSTCQE
   301  PSCCVSSICQ PICSEPSPCS PAVCVSSPCQ PTCYVVKRCP SVCPEPVSCP STSCRPLSCS
   361  PGSSASAICR PTCPRTFYIP SSSKRPCSAT ISYRPVSRPI CRPICSGLLT YRQPYMTSIS
   421  YRPACYRPCY SILRRPACVT SYSCRPVYFR PSCTESDSCK RDCKKSTSSQ LDCVDTTPCK
   481  VDVSEEAPCQ PTEAKPISPT TREAAAAQPA ASKPANC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTAP16-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

skin: 15 nTPM
bone marrow: 0.9 nTPM
adipose tissue: 0.3 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

memory CD4 T-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM
neutrophil: 0.2 nTPM
naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
gnomAD missense Z: 0.74
DepMap mean gene effect: -0.06
DepMap dependency class: selective

OntologyGO

Molecular functions

structural molecule activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTAP16-1 as an antibody target. Whether an autoantibody or antibody against KRTAP16-1 could matter depends on whether native KRTAP16-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTAP16-1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTAP16-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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