Seroatlas · Human Serome Atlas

KRTAP2-2

Keratin-associated protein 2-2

Also known as: KAP2.2, KRA22_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BYT5
Gene
KRTAP2-2
Ensembl
ENSG00000214518
Chromosome
17
Canonical length
123 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>Q9BYT5|KRTAP2-2
     1  MTGSCCGSTF SSLSYGGGCC QPCCCRDPCC CRPVTCQTTV CRPVTCVPRC TRPICEPCRR
    61  PVCCDPCSLQ EGCCRPITCC PSSCTAVVCR PCCWATTCCQ PVSVQSPCGQ PTPCSTTCRT
   121  SSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTAP2-2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • skin: 49 nTPM
  • salivary gland: 0.8 nTPM
  • adipose tissue: 0.1 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • loop of henle epithelial cells: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.54
gnomAD pLI
0.45
gnomAD missense Z
0.38

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTAP2-2 as an antibody target. Whether an autoantibody or antibody against KRTAP2-2 could matter depends on whether native KRTAP2-2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTAP2-2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTAP2-2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRTAP2-2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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