Seroatlas · Human Serome Atlas

KRTAP10-8

Keratin-associated protein 10-8

Also known as: KAP10.8, KR108_HUMAN, KRTAP18-8, KRTAP18.8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60410
Gene: KRTAP10-8
Ensembl: ENSG00000187766
Chromosome: 21
Canonical length: 259 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>P60410|KRTAP10-8
     1  MADACCTRTY VIAASTMSVC SSDVGHVSRV SSPSTCTGSS WQVDNCQESC CEPRSCASSC
    61  CTPSCCAPAP CLALVCAPVS CEPSPCQSGC TDSCTPSCCQ QSSCQPACCT SSPCQQACCV
   121  PVCCKSNCCK PVCCVSICSG ASSPCCQQSS CQSACCTFSP CQQACCVPIC CKPICCVPVC
   181  SGASSLCCQK SSCQPACCTT SCCRPSSSVS LLCRPVCRPA CCVPVPSCCV PASSCQPSCC
   241  HPASCLSFLC RPACSRLAC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTAP10-8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72
Highest tissue expression: 7 nTPM

Expression across tissuesHPA

Tissue

skin: 7 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

cardiomyocytes: 0.2 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 0.3 nTPM
basal ganglia: 0.1 nTPM
amygdala: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: -0.67
DepMap mean gene effect: 0.01
DepMap dependency class: selective

OntologyGO

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRTAP10-8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTAP10-8 as an antibody target. Whether an autoantibody or antibody against KRTAP10-8 could matter depends on whether native KRTAP10-8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTAP10-8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTAP10-8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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