Seroatlas · Human Serome Atlas

KRTAP10-4

Keratin-associated protein 10-4

Also known as: KAP10.4, KR104_HUMAN, KRTAP18-4, KRTAP18.4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60372
Gene: KRTAP10-4
Ensembl: ENSG00000215454
Chromosome: 21
Canonical length: 401 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This is an intronless gene located in a cluster of related genes on the q arm of chromosome 21. The proteins encoded by these genes form disulfide bonds with cysteine residues in hair keratins, thereby contributing to the structure and stability of hair fibers. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

401 residues, UniProt reviewed canonical sequence.

>P60372|KRTAP10-4
     1  MSVCSSDLSY SSRVCLPGSC DSCSDSWQVD DCPESCCEPP CCAPSCCAPA PCLSLVCTPV
    61  SRVSSPCCPV TCEPSPCQSG CTSSCTPSCC QQSSCQLACC ASSPCQQACC VPVCCKTVCC
   121  KPVCCVPVCC GDSSCCQQSS CQSACCTSSP CQQACCVPIC CKPVCSGISS SCCQQSSCVS
   181  CVSSPCCQAV CEPSPCQSGC ISSCTPSCCQ QSSCQPACCT SSSCQQACCV PVCCKTVCCK
   241  PVCSEDSSSC CQQSSCQPAC CTSSPCQQAC CVPVCCKPVC CKPVCSVPIC SGASSLCCQQ
   301  SSCQPACCTS SQSQQGCCVP VCCKPVSCVP VCSGASSSCC QQSSCQPACC TTSCCRPSSS
   361  VSLLCRPVCR PACCVPVPSC CAPTSSCQPS CCRPASCVSL L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTAP10-4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72
Highest tissue expression: 6.9 nTPM

Expression across tissuesHPA

Tissue

skin: 6.9 nTPM
adipose tissue: 0.1 nTPM
fallopian tube: 0.1 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

podocytes: 2.3 nCPM
brain inhibitory neurons: 0.7 nCPM
distal convoluted tubule cells: 0.4 nCPM
other brain neurons: 0.4 nCPM
choroid plexus epithelial cells: 0.2 nCPM
renal collecting duct intercalated cells: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: -1.38

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTAP10-4 as an antibody target. Whether an autoantibody or antibody against KRTAP10-4 could matter depends on whether native KRTAP10-4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTAP10-4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTAP10-4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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