Seroatlas · Human Serome Atlas

KRTAP10-2

Keratin-associated protein 10-2

Also known as: KAP10.2, KAP18.2, KR102_HUMAN, KRTAP18-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60368
Gene: KRTAP10-2
Ensembl: ENSG00000205445
Chromosome: 21
Canonical length: 255 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the high sulfur-type keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. This gene is located in a cluster of similar genes on 21q22.3. Alternatively-spliced transcript variants have been identified. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>P60368|KRTAP10-2
     1  MAASTMSICS SACTNSWQVD DCPESCCELP CGTPSCCAPA PCLTLVCTPV SCVSSPCCQA
    61  ACEPSACQSG CTSSCTPSCC QQSSCQPACC TSSPCQQACC VPVCCKPVCC VPVCCGASSC
   121  CQQSSCQPAC CASSSCQQSC RVPVCCKAVC CVPTCSESSS SCCQQSSCQP ACCTSSPCQQ
   181  SCCVSVCCKP VCCKSICCVP VCSGASSPCC QQSSCQPACC TSSCCRPSSS VSLLCRPVCS
   241  RPASCSFSSG QKSSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTAP10-2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

skin: 14 nTPM
adipose tissue: 0.1 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

fallopian secretory cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM

Immune cell

neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
choroid plexus: 0.3 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
medulla oblongata: 0.1 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0.35
gnomAD missense Z: -1.08
DepMap mean gene effect: 0.1
DepMap dependency class: none

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTAP10-2 as an antibody target. Whether an autoantibody or antibody against KRTAP10-2 could matter depends on whether native KRTAP10-2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTAP10-2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTAP10-2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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