Seroatlas · Human Serome Atlas

KRTAP10-7

Keratin-associated protein 10-7

Also known as: KAP10.7, KAP18.7, KR107_HUMAN, KRTAP18-7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60409
Gene: KRTAP10-7
Ensembl: ENSG00000272804
Chromosome: 21
Canonical length: 370 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

370 residues, UniProt reviewed canonical sequence.

>P60409|KRTAP10-7
     1  MAASTMSVCS SDLSYGSRVC LPGSCDSCSD SWQVDDCPES CCEPPCCAPA PCLSLVCTPV
    61  SYVSSPCCRV TCEPSPCQSG CTSSCTPSCC QQSSCQLACC ASSPCQQACC VPVCCKTVCC
   121  KPVYCVPVCS GDSSCCQQSS CQSACCTSSP CQQACCVPIC CKPVCSGISS SCCQQSSCVS
   181  CVSSPCCQAV CEPSPCQSGC ISSCTPSCCQ QSSCKPACCT SSPCQQACCV PVCCKPVCCV
   241  PTCSDDSGSC CQPACCTSSQ SQQGCCVPVC CKPVCCVPVC SGASTSCCQQ SSCQPACCTT
   301  SCCRPSSSVS LLCRPVCRPA CCVPVPSCCA PTSSCQASCC RPASCVSLLC RPACSRPACC
   361  GPTSTQKSSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTAP10-7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

skin: 13 nTPM
adipose tissue: 0.2 nTPM
pituitary gland: 0.1 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

corticotrophs: 0.3 nCPM
cardiomyocytes: 0.2 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0
gnomAD missense Z: -1.66

OntologyGO

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRTAP10-7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTAP10-7 as an antibody target. Whether an autoantibody or antibody against KRTAP10-7 could matter depends on whether native KRTAP10-7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTAP10-7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTAP10-7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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