KRTAP10-3
Keratin-associated protein 10-3
Also known as: KAP10.3, KAP18.3, KR103_HUMAN, KRTAP18-3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P60369
- Gene
- KRTAP10-3
- Ensembl
- ENSG00000212935
- Chromosome
- 21
- Canonical length
- 221 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
This gene encodes a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This gene encodes a member of the high sulfur KAP family. It is localized to a cluster of intronless KAPs at 21q22.3 which are located within the introns of the C21orf29 gene. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
221 residues, UniProt reviewed canonical sequence.
>P60369|KRTAP10-3
1 MATSTMSVCS SAYSDSWQVD ACPESCCEPP CCATSCCAPA PCLTLVCTPV SCVSSPCCQA
61 ACEPSPCQSG CTSSCTPSCC QQSSCQPACC TSSPCQQACC VPVCCKPVCC VPVCCKPVCC
121 KPICCVPVCS GASSSCCQQS SRQPACCTTS CCRPSSSVSL LCRPVCRSTC CVPIPSCCAP
181 ASTCQPSCCR PASCVSLLCR PTCSRLSSAC CGLSSGQKSS CLocalizationUniProt · AlphaFold · HPA
Whether an antibody against KRTAP10-3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.7
- Highest tissue expression
- 22 nTPM
Expression across tissuesHPA
Tissue
- skin: 22 nTPM
- adipose tissue: 0.2 nTPM
- choroid plexus: 0.1 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- choroid plexus: 0.3 nTPM
- cerebral cortex: 0.2 nTPM
- basal ganglia: 0.1 nTPM
- hypothalamus: 0.1 nTPM
- medulla oblongata: 0.1 nTPM
- midbrain: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.41
- gnomAD pLI
- 0.02
- gnomAD missense Z
- -1.68
- DepMap mean gene effect
- -0.19
- DepMap dependency class
- selective
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KRTAP10-3 as an antibody target. Whether an autoantibody or antibody against KRTAP10-3 could matter depends on whether native KRTAP10-3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KRTAP10-3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label KRTAP10-3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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