KRTAP10-5
Keratin-associated protein 10-5
Also known as: KAP10.5, KAP18.5, KR105_HUMAN, KRTAP18-5
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P60370
- Gene
- KRTAP10-5
- Ensembl
- ENSG00000241123
- Chromosome
- 21
- Canonical length
- 271 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
This is an intronless gene located in a cluster of related genes on the q arm of chromosome 21. The proteins encoded by these genes form disulfide bonds with cysteine residues in hair keratins, thereby contributing to the structure and stability of hair fibers. [provided by RefSeq, Apr 2014]
Canonical amino-acid sequenceUniProt
271 residues, UniProt reviewed canonical sequence.
>P60370|KRTAP10-5
1 MAACTMSVCS SACSDSWRVD DCPESCCEPP CGTAPCLTLV CTPVSCVSSP CCQAACEPSP
61 CQSGCTSSCT PSCCQPACCA SSPCQQACCV PVCCKPVCCL PTCSKDSSSC CQQSSCQPTC
121 CASSSCQQSC CVPVCCKPVC CVPTCSEDSS SCCQHSSCQP TCCTSSPCQQ SCYVPVCCKP
181 VCCKPICCVP VCSGASTSCC QQSSCQPACC TTSCCRPSSS VSLLCRPICR PACCLPISSC
241 CAPASSYQAS CCRPASCVSL LCRPACSPLA CLocalizationUniProt · AlphaFold · HPA
Whether an antibody against KRTAP10-5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.7
- Highest tissue expression
- 15 nTPM
Expression across tissuesHPA
Tissue
- skin: 15 nTPM
- adipose tissue: 0.2 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- choroid plexus: 0.2 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.4
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.58
- DepMap mean gene effect
- 0.2
- DepMap dependency class
- none
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of KRTAP10-5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KRTAP10-5 as an antibody target. Whether an autoantibody or antibody against KRTAP10-5 could matter depends on whether native KRTAP10-5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KRTAP10-5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label KRTAP10-5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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