Seroatlas · Human Serome Atlas

KRTAP4-12

Keratin-associated protein 4-12

Also known as: KAP4.12, KR412_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQ66
Gene: KRTAP4-12
Ensembl: ENSG00000213416
Chromosome: 17
Canonical length: 201 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>Q9BQ66|KRTAP4-12
     1  MVNSCCGSVC SDQGCGLENC CRPSCCQTTC CRTTCCRPSC CVSSCCRPQC CQSVCCQPTC
    61  CRPSCCQTTC CRTTCCRPSC CVSSCCRPQC CQSVCCQPTC CRPSCCQTTC CRTTCCRPSC
   121  CVSSCCRPQC CQSVCCQPTC CRPSCCISSS CCPSCCESSC CRPCCCLRPV CGRVSCHTTC
   181  YRPTCVISTC PRPLCCASSC C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTAP4-12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

skin: 24 nTPM
salivary gland: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

naive B-cell: 1 nTPM
naive CD8 T-cell: 0.2 nTPM
naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0.19
gnomAD missense Z: -1.05

OntologyGO

Biological processes

hair cycle

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRTAP4-12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTAP4-12 as an antibody target. Whether an autoantibody or antibody against KRTAP4-12 could matter depends on whether native KRTAP4-12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTAP4-12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTAP4-12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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