Seroatlas · Human Serome Atlas

KRTAP4-16

Keratin-associated protein 4-16

Also known as: KAP4A, KR416_HUMAN, KRTAP4-16P, KRTAP4P1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
G5E9R7
Gene
KRTAP4-16
Ensembl
ENSG00000241241
Chromosome
17
Canonical length
235 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in cytosol and keratin filament. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>G5E9R7|KRTAP4-16
     1  MCSSKMPCSP SASSLCAASP PNCCHPSCCQ TTCCRTTSCS HSCSVSSCCR PQCCHSVCCQ
    61  PTCCRPSCCQ TTCCRTTCCH PSCCVSSCCR PQCCHSVCFQ PTCCHPSCCI SSSCCPSCCE
   121  SSCCCPCCCL RPVCGRVSCH VTCYHPTCVI STCPHPLCCA SPPLPLPFPS PPVPLPFFLS
   181  LALPSPPRPS PPLLSPVLIP SPSPSPSLPS LSPPLPSPPL PSPHFPSVNP KSMLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTAP4-16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
0 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM
  • blood vessel: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 2.8 nTPM
  • pons: 2.7 nTPM
  • medulla oblongata: 2.5 nTPM
  • thalamus: 2.4 nTPM
  • hypothalamus: 2.3 nTPM
  • amygdala: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0
gnomAD pLI
0

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTAP4-16 as an antibody target. Whether an autoantibody or antibody against KRTAP4-16 could matter depends on whether native KRTAP4-16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTAP4-16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTAP4-16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRTAP4-16. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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