KRTAP9-7
Keratin-associated protein 9-7
Also known as: KAP9.7, KRA97_HUMAN, KRTAP9L1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A8MTY7
- Gene
- KRTAP9-7
- Ensembl
- ENSG00000180386
- Chromosome
- 17
- Canonical length
- 169 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
169 residues, UniProt reviewed canonical sequence.
>A8MTY7|KRTAP9-7
1 MTHCCSPCCQ PTCCRTTCWK PTTVTTCSST PCCQPSCCVS SCCQPCCHPT CCQNTCCRTT
61 CCQPTCVTSC CQPSCCSTPC CQPICCGSSC CGQTSCGSSC CQPSSCAPIY CRRTCYHPTS
121 VYLPGCLNQS CGSSCCQPCC RPACCETTCC RTTCFQPTCV TSCCQPACCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against KRTAP9-7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.67
- Highest tissue expression
- 7.8 nTPM
Expression across tissuesHPA
Tissue
- skin: 7.8 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about KRTAP9-7.
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 1 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.88
- gnomAD pLI
- 0.3
- gnomAD missense Z
- -0.61
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KRTAP9-7 as an antibody target. Whether an autoantibody or antibody against KRTAP9-7 could matter depends on whether native KRTAP9-7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KRTAP9-7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label KRTAP9-7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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