Seroatlas · Human Serome Atlas

TUBB

Tubulin beta chain

Also known as: M40, MGC16435, OK/SW-cl.56, TBB5_HUMAN, Tubb5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P07437
Gene
TUBB
Ensembl
ENSG00000196230
Chromosome
6
Canonical length
444 aa
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Microtubules,Cytokinetic bridge,Mitotic spindle,Primary cilium,Basal body,Flagellar centriole,Principal piece,End piece

OverviewNCBI Gene

This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]

Canonical amino-acid sequenceUniProt

444 residues, UniProt reviewed canonical sequence.

>P07437|TUBB
     1  MREIVHIQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLDRISVY YNEATGGKYV
    61  PRAILVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDSVLDVV
   121  RKEAESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEYP DRIMNTFSVV PSPKVSDTVV
   181  EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL
   241  RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQVFDAKNMM
   301  AACDPRHGRY LTVAAVFRGR MSMKEVDEQM LNVQNKNSSY FVEWIPNNVK TAVCDIPPRG
   361  LKMAVTFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS
   421  EYQQYQDATA EEEEDFGEEA EEEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUBB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
578 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 578 nTPM
  • bone marrow: 510 nTPM
  • tonsil: 457 nTPM
  • ovary: 439 nTPM
  • endometrium: 347 nTPM
  • smooth muscle: 346 nTPM

Single-cell type

  • other brain neurons: 171 nCPM
  • brain excitatory neurons: 62 nCPM
  • brain inhibitory neurons: 52 nCPM
  • microglia: 43 nCPM
  • renal collecting duct principal cells: 43 nCPM
  • oligodendrocyte progenitor cells: 34 nCPM

Immune cell

  • total PBMC: 342 nTPM
  • plasmacytoid DC: 228 nTPM
  • non-classical monocyte: 223 nTPM
  • MAIT T-cell: 219 nTPM
  • memory CD8 T-cell: 189 nTPM
  • gdT-cell: 188 nTPM

Brain region

  • hypothalamus: 278 nTPM
  • pons: 235 nTPM
  • choroid plexus: 208 nTPM
  • medulla oblongata: 194 nTPM
  • basal ganglia: 191 nTPM
  • midbrain: 183 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TUBB.

Disease | AllUniProt

Conditions TUBB is implicated in, by any mechanism.

  • Cortical dysplasia, complex, with other brain malformations 6 (CDCBM6) MIM:615771
  • Skin creases, congenital symmetric circumferential, 1 (CSCSC1) MIM:156610

Disease | GeneticClinVar

38 pathogenic / likely-pathogenic of 128 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on TUBB was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.98
gnomAD missense Z
5.63
DepMap mean gene effect
-1.67
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TUBB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUBB as an antibody target. Whether an autoantibody or antibody against TUBB could matter depends on whether native TUBB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUBB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUBB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TUBB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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