Seroatlas · Human Serome Atlas

TCP11L1

T-complex protein 11-like protein 1

Also known as: FLJ11336, T11L1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NUJ3
Gene: TCP11L1
Ensembl: ENSG00000176148
Chromosome: 11
Canonical length: 509 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to be involved in signal transduction. Located in microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

509 residues, UniProt reviewed canonical sequence.

>Q9NUJ3|TCP11L1
     1  MSENLDKSNV NEAGKSKSND SEEGLEDAVE GADEALQKAI KSDSSSPQRV QRPHSSPPRF
    61  VTVEELLETA RGVTNMALAH EIVVNGDFQI KPVELPENSL KKRVKEIVHK AFWDCLSVQL
   121  SEDPPAYDHA IKLVGEIKET LLSFLLPGHT RLRNQITEVL DLDLIKQEAE NGALDISKLA
   181  EFIIGMMGTL CAPARDEEVK KLKDIKEIVP LFREIFSVLD LMKVDMANFA ISSIRPHLMQ
   241  QSVEYERKKF QEILERQPNS LDFVTQWLEE ASEDLMTQKY KHALPVGGMA AGSGDMPRLS
   301  PVAVQNYAYL KLLKWDHLQR PFPETVLMDQ SRFHELQLQL EQLTILGAVL LVTFSMAAPG
   361  ISSQADFAEK LKMIVKILLT DMHLPSFHLK DVLTTIGEKV CLEVSSCLSL CGSSPFTTDK
   421  ETVLKGQIQA VASPDDPIRR IMESRILTFL ETYLASGHQK PLPTVPGGLS PVQRELEEVA
   481  IKFARLVNYN KMVFCPYYDA ILSKILVRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCP11L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 12 nTPM
small intestine: 8.4 nTPM
smooth muscle: 8.1 nTPM
blood vessel: 8 nTPM
gallbladder: 7.6 nTPM
bone marrow: 7 nTPM

Single-cell type

pituitary stem cells: 143 nCPM
enterocytes: 96 nCPM
epididymal basal cells: 93 nCPM
tuft cells: 92 nCPM
proximal tubule cells: 82 nCPM
fibro-adipogenic progenitors: 71 nCPM

Immune cell

basophil: 19 nTPM
plasmacytoid DC: 11 nTPM
eosinophil: 8.8 nTPM
classical monocyte: 6.1 nTPM
myeloid DC: 5.9 nTPM
T-reg: 5.9 nTPM

Brain region

midbrain: 57 nTPM
cerebral cortex: 56 nTPM
pons: 55 nTPM
hypothalamus: 53 nTPM
basal ganglia: 52 nTPM
white matter: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0
gnomAD missense Z: 1.25
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Cellular components

microtubule

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of TCP11L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TUBB4B

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCP11L1 as an antibody target. Whether an autoantibody or antibody against TCP11L1 could matter depends on whether native TCP11L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCP11L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCP11L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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