Beta tubulin, autoregulation binding site

Definition

The stability of beta-tubulin mRNAs are autoregulated by their own translation product PMID:3072712. Unpolymerised tubulin subunits bind directly (or activate a factor(s) which binds co-translationally) to the nascent N terminus of beta-tubulin. This binding is transduced through the adjacent ribosomes to activate an RNAse that degrades the polysome-bound mRNA. The recognition element has been shown to be the first four amino acids of beta-tubulin: Met-Arg-Glu-Ile. Mutations to this sequence abolish the autoregulation effect (except for the replacement of Glu by Asp); transposition of this sequence to an internal region of a polypeptide also suppresses the autoregulatory effect.

10 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (10 proteins: gene, accession, name)

• TUBB
• TUBB1
• TUBB2A
• TUBB2B
• TUBB3
• TUBB4A
• TUBB4B
• TUBB6
• TUBB8
• TUBB8B