TBCA

Protein identityUniProt · HPA

UniProt accession

O75347

Gene

TBCA

Ensembl

ENSG00000171530

Chromosome

5

Canonical length

108 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoli,Microtubules

OverviewNCBI Gene

The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

108 residues, UniProt reviewed canonical sequence.

>O75347|TBCA
     1  MADPRVRQIK IKTGVVKRLV KEKVMYEKEA KQQEEKIEKM RAEDGENYDI KKQAEILQES
    61  RMMIPDCQRR LEAAYLDLQR ILENEKDLEE AEEYKEARLV LDSVKLEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBCA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

267 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.02

gnomAD pLI

0.16

gnomAD missense Z

0.6

DepMap mean gene effect

-0.9

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• post-chaperonin tubulin folding pathway
• protein folding
• tubulin complex assembly

Molecular functions

• beta-tubulin binding
• protein-folding chaperone binding
• RNA binding
• tubulin binding

Cellular components

• cytoplasm
• microtubule
• microtubule cytoskeleton
• nucleolus

Protein domainsUniProt · Pfam · InterPro

• Tubulin binding cofactor A
• Tubulin binding cofactor A superfamily
• Tubulin binding cofactor A

KeywordsUniProt

• Acetylation
• Chaperone
• Cytoplasm
• Cytoskeleton
• Microtubule

InteractionsUniProt · HPA

Protein binding partners of TBCA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TUBB4B