Seroatlas · Human Serome Atlas

LNX2

Ligand of Numb protein X 2

Also known as: LNX2_HUMAN, MGC46315, PDZRN1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N448
Gene: LNX2
Ensembl: ENSG00000139517
Chromosome: 13
Canonical length: 690 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable ubiquitin-protein transferase activity. Predicted to act upstream of or within neural precursor cell proliferation and neuron differentiation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

690 residues, UniProt reviewed canonical sequence.

>Q8N448|LNX2
     1  MGTTSDEMVS VEQTSSSSLN PLCFECGQQH WTRENHLYNY QNEVDDDLVC HICLQPLLQP
    61  LDTPCGHTFC YKCLRNFLQE KDFCPLDRKR LHFKLCKKSS ILVHKLLDKL LVLCPFSSVC
   121  KDVMQRCDLE AHLKNRCPGA SHRRVALERR KTSRTQAEIE NENGPTLLDP AGTLSPEADC
   181  LGTGAVPVER HLTSASLSTW SEEPGLDNPA FEESAGADTT QQPLSLPEGE ITTIEIHRSN
   241  PYIQLGISIV GGNETPLINI VIQEVYRDGV IARDGRLLAG DQILQVNNYN ISNVSHNYAR
   301  AVLSQPCNTL HLTVLRERRF GNRAHNHSDS NSPREEIFQV ALHKRDSGEQ LGIKLVRRTD
   361  EPGVFILDLL EGGLAAQDGR LSSNDRVLAI NGHDLKYGTP ELAAQIIQAS GERVNLTIAR
   421  PGKPQPGNTI REAGNHSSSS QHHTPPPYYS RPSSHKDLTQ CVTCQEKHIT VKKEPHESLG
   481  MTVAGGRGSK SGELPIFVTS VPPHGCLARD GRIKRGDVLL NINGIDLTNL SHSEAVAMLK
   541  ASAASPAVAL KALEVQIVEE ATQNAEEQPS TFSENEYDAS WSPSWVMWLG LPSTLHSCHD
   601  IVLRRSYLGS WGFSIVGGYE ENHTNQPFFI KTIVLGTPAY YDGRLKCGDM IVAVNGLSTV
   661  GMSHSALVPM LKEQRNKVTL TVICWPGSLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LNX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

liver: 19 nTPM
pancreas: 18 nTPM
duodenum: 13 nTPM
small intestine: 13 nTPM
testis: 12 nTPM
lung: 11 nTPM

Single-cell type

podocytes: 244 nCPM
alveolar cells type 1: 210 nCPM
alveolar cells type 2: 208 nCPM
transitional alveolar cells: 185 nCPM
esophageal apical cells: 143 nCPM
pancreatic acinar cells: 137 nCPM

Immune cell

basophil: 2 nTPM
NK-cell: 1.1 nTPM
T-reg: 1 nTPM
eosinophil: 0.9 nTPM
MAIT T-cell: 0.7 nTPM
memory CD8 T-cell: 0.7 nTPM

Brain region

choroid plexus: 15 nTPM
cerebellum: 12 nTPM
hypothalamus: 6.6 nTPM
cerebral cortex: 5.9 nTPM
hippocampal formation: 5.7 nTPM
thalamus: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0
gnomAD missense Z: 0.71
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LNX2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LNX2 as an antibody target. Whether an autoantibody or antibody against LNX2 could matter depends on whether native LNX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LNX2 is annotated at the cell surface, where native LNX2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LNX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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