RPL23

Protein identityUniProt · HPA

UniProt accession

P62829

Gene

RPL23

Ensembl

ENSG00000125691

Chromosome

17

Canonical length

140 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Ribosomal proteins

Subcellular location

Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>P62829|RPL23
     1  MSKRGRGGSS GAKFRISLGL PVGAVINCAD NTGAKNLYII SVKGIKGRLN RLPAAGVGDM
    61  VMATVKKGKP ELRKKVHPAV VIRQRKSYRR KDGVFLYFED NAGVIVNNKG EMKGSAITGP
   121  VAKECADLWP RIASNAGSIA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

4,082 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.74

gnomAD pLI

0.33

gnomAD missense Z

1.95

DepMap mean gene effect

-2.65

DepMap dependency class

pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cytoplasmic translation
• G1 to G0 transition
• negative regulation of transcription by RNA polymerase II
• negative regulation of ubiquitin-dependent protein catabolic process
• positive regulation of cell population proliferation
• positive regulation of signal transduction by p53 class mediator
• protein stabilization
• protein-DNA complex disassembly
• regulation of G1 to G0 transition
• ribosomal protein import into nucleus
• translation

Molecular functions

• large ribosomal subunit rRNA binding
• RNA binding
• structural constituent of ribosome
• transcription coactivator binding
• ubiquitin ligase inhibitor activity
• ubiquitin protein ligase binding

Cellular components

• cytoplasm
• cytosol
• cytosolic large ribosomal subunit
• cytosolic ribosome
• extracellular exosome
• focal adhesion
• membrane
• nucleolus
• nucleoplasm
• protein-containing complex
• ribosome
• synapse

Protein domainsUniProt · Pfam · InterPro

• Large ribosomal subunit protein uL14
• Large ribosomal subunit protein uL14 superfamily
• Ribosomal protein L14p/L23e
• Large ribosomal subunit protein uL14, conserved site

KeywordsUniProt

• Cytoplasm
• Phosphoprotein
• Ribonucleoprotein
• Ribosomal protein

InteractionsUniProt · HPA

Protein binding partners of RPL23 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BCCIP
• MDM2
• RPL5
• TUBB