Seroatlas · Human Serome Atlas

CFAP157

Cilia- and flagella-associated protein 157

Also known as: C9orf117, CF157_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5JU67
Gene
CFAP157
Ensembl
ENSG00000160401
Chromosome
9
Canonical length
520 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Predicted to be involved in sperm axoneme assembly. Predicted to be located in cilium; cytoplasm; and cytoskeleton. Predicted to be active in ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q5JU67|CFAP157
     1  MAPKKSVSKA GKELEVKKKG GKKEPVVAVE PPLAKEMKEF YHIQIRDLED RLARYQRKWD
    61  ELAVQEKMFR QEFEQLANNK KEIVAFLKRT LNQQVDEITD LNEQLQNLQL AKEMEKDAFE
   121  AQLAQVRHEF QETKDQLTTE NIILGGKLAA LEEFRLQKEE VTDKFTLLEE QVRKQENEFR
   181  DYAYNLEKKS VLDKDRLRKE IIQRVNLVAN EFHKVTTNRM WETTKRAIKE NNGITLQMAR
   241  VSQQGMKLLQ ENEQLKGRQN NLCKQLELLE NTQKVMARHK RGHQKIILML TKKCQEQQQD
   301  TKEAEELRLL LSQLEQRSLQ LQVDNQALKS QRDQLSLQLE QQQVDLQRLQ QELANEQKVR
   361  ASLEAALVQA TSFLQNILQM HRDEEDSDVD VTFQPWHKEM LQQLLVMLSS TVATRPQKAA
   421  CPHQESQSHG PPKESRPSIQ LPRTGSLLPQ LSDITPYQPG DLGLVPRQVH IPPNPQDLRL
   481  LSYITRVGTF RAHSSPEMRA PGSLKRLEKF SLPEVPLRPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP157 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 48 nTPM
  • choroid plexus: 37 nTPM
  • lung: 11 nTPM
  • hypothalamus: 9.7 nTPM
  • basal ganglia: 8.9 nTPM
  • testis: 8.9 nTPM

Single-cell type

  • respiratory ciliated cells: 901 nCPM
  • fallopian tube ciliated cells: 807 nCPM
  • ependymal cells: 676 nCPM
  • epididymal efferent duct ciliated cells: 604 nCPM
  • endometrial ciliated cells: 487 nCPM
  • late spermatids: 151 nCPM

Immune cell

  • MAIT T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 76 nTPM
  • midbrain: 40 nTPM
  • medulla oblongata: 30 nTPM
  • spinal cord: 17 nTPM
  • pons: 14 nTPM
  • hypothalamus: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Cilia- and flagella-associated protein 157

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CFAP157 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP157 as an antibody target. Whether an autoantibody or antibody against CFAP157 could matter depends on whether native CFAP157 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP157 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP157 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CFAP157. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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