Seroatlas · Human Serome Atlas

TRAPPC2

Trafficking protein particle complex subunit 2

Also known as: hYP38334, MIP-2A, SEDL, SEDT, TPC2A_HUMAN, TRS20, ZNF547L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DI81
Gene
TRAPPC2
Ensembl
ENSG00000196459
Chromosome
X
Canonical length
140 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Endoplasmic reticulum,Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>P0DI81|TRAPPC2
     1  MSGSFYFVIV GHHDNPVFEM EFLPAGKAES KDDHRHLNQF IAHAALDLVD ENMWLSNNMY
    61  LKTVDKFNEW FVSAFVTAGH MRFIMLHDIR QEDGIKNFFT DVYDLYIKFS MNPFYEPNSP
   121  IRSSAFDRKV QFLGKKHLLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAPPC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 17 nTPM
  • cerebral cortex: 11 nTPM
  • hypothalamus: 11 nTPM
  • basal ganglia: 11 nTPM
  • lymph node: 11 nTPM
  • hippocampal formation: 11 nTPM

Single-cell type

  • platelets: 133 nCPM
  • cardiomyocytes: 68 nCPM
  • nk-cells: 63 nCPM
  • esophageal apical cells: 58 nCPM
  • parietal cells: 51 nCPM
  • epicardial cells: 48 nCPM

Immune cell

  • NK-cell: 22 nTPM
  • basophil: 19 nTPM
  • gdT-cell: 17 nTPM
  • MAIT T-cell: 17 nTPM
  • T-reg: 16 nTPM
  • memory CD8 T-cell: 16 nTPM

Brain region

  • hypothalamus: 27 nTPM
  • cerebral cortex: 24 nTPM
  • hippocampal formation: 23 nTPM
  • basal ganglia: 23 nTPM
  • cerebellum: 22 nTPM
  • amygdala: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRAPPC2.

Disease | AllUniProt

Conditions TRAPPC2 is implicated in, by any mechanism.

  • Spondyloepiphyseal dysplasia tarda (SEDT) MIM:313400

Disease | GeneticClinVar

36 pathogenic / likely-pathogenic of 173 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.75
gnomAD pLI
0
gnomAD missense Z
1.53

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAPPC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAPPC2 as an antibody target. Whether an autoantibody or antibody against TRAPPC2 could matter depends on whether native TRAPPC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAPPC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAPPC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRAPPC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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