Seroatlas · Human Serome Atlas

TRAPPC8

Trafficking protein particle complex subunit 8

Also known as: GSG1, HsT2706, KIAA1012, TPPC8_HUMAN, TRS85

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2L5
Gene: TRAPPC8
Ensembl: ENSG00000153339
Chromosome: 18
Canonical length: 1435 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Cytosol

OverviewNCBI Gene

Involved in Golgi organization and collagen biosynthetic process. Part of TRAPP complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1435 residues, UniProt reviewed canonical sequence.

>Q9Y2L5|TRAPPC8
     1  MAQCVQSVQE LIPDSFVPCV AALCSDEAER LTRLNHLSFA ELLKPFSRLT SEVHMRDPNN
    61  QLHVIKNLKI AVSNIVTQPP QPGAIRKLLN DVVSGSQPAE GLVANVITAG DYDLNISATT
   121  PWFESYRETF LQSMPALDHE FLNHYLACML VASSSEAEPV EQFSKLSQEQ HRIQHNSDYS
   181  YPKWFIPNTL KYYVLLHDVS AGDEQRAESI YEEMKQKYGT QGCYLLKINS RTSNRASDEQ
   241  IPDPWSQYLQ KNSIQNQESY EDGPCTITSN KNSDNNLLSL DGLDNEVKDG LPNNFRAHPL
   301  QLEQSSDPSN SIDGPDHLRS ASSLHETKKG NTGIIHGACL TLTDHDRIRQ FIQEFTFRGL
   361  LPHIEKTIRQ LNDQLISRKG LSRSLFSATK KWFSGSKVPE KSINDLKNTS GLLYPPEAPE
   421  LQIRKMADLC FLVQHYDLAY SCYHTAKKDF LNDQAMLYAA GALEMAAVSA FLQPGAPRPY
   481  PAHYMDTAIQ TYRDICKNMV LAERCVLLSA ELLKSQSKYS EAAALLIRLT SEDSDLRSAL
   541  LLEQAAHCFI NMKSPMVRKY AFHMILAGHR FSKAGQKKHA LRCYCQAMQV YKGKGWSLAE
   601  DHINFTIGRQ SYTLRQLDNA VSAFRHILIN ESKQSAAQQG AFLREYLYVY KNVSQLSPDG
   661  PLPQLPLPYI NSSATRVFFG HDRRPADGEK QAATHVSLDQ EYDSESSQQW RELEEQVVSV
   721  VNKGVIPSNF HPTQYCLNSY SDNSRFPLAV VEEPITVEVA FRNPLKVLLL LTDLSLLWKF
   781  HPKDFSGKDN EEVKQLVTSE PEMIGAEVIS EFLINGEESK VARLKLFPHH IGELHILGVV
   841  YNLGTIQGSM TVDGIGALPG CHTGKYSLSM SVRGKQDLEI QGPRLNNTKE EKTSVKYGPD
   901  RRLDPIITEE MPLLEVFFIH FPTGLLCGEI RKAYVEFVNV SKCPLTGLKV VSKRPEFFTF
   961  GGNTAVLTPL SPSASENCSA YKTVVTDATS VCTALISSAS SVDFGIGTGS QPEVIPVPLP
  1021  DTVLLPGASV QLPMWLRGPD EEGVHEINFL FYYESVKKQP KIRHRILRHT AIICTSRSLN
  1081  VRATVCRSNS LENEEGRGGN MLVFVDVENT NTSEAGVKEF HIVQVSSSSK HWKLQKSVNL
  1141  SENKDTKLAS REKGKFCFKA IRCEKEEAAT QSSEKYTFAD IIFGNEQIIS SASPCADFFY
  1201  RSLSSELKKP QAHLPVHTEK QSTEDAVRLI QKCSEVDLNI VILWKAYVVE DSKQLILEGQ
  1261  HHVILRTIGK EAFSYPQKQE PPEMELLKFF RPENITVSSR PSVEQLSSLI KTSLHYPESF
  1321  NHPFHQKSLC LVPVTLLLSN CSKADVDVIV DLRHKTTSPE ALEIHGSFTW LGQTQYKLQL
  1381  KSQEIHSLQL KACFVHTGVY NLGTPRVFAK LSDQVTVFET SQQNSMPALI IISNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAPPC8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

testis: 28 nTPM
retina: 19 nTPM
liver: 17 nTPM
skeletal muscle: 17 nTPM
thymus: 15 nTPM
parathyroid gland: 14 nTPM

Single-cell type

neutrophils: 255 nCPM
neutrophil progenitors: 167 nCPM
microglia: 148 nCPM
myonuclei: 144 nCPM
choroid plexus epithelial cells: 134 nCPM
thyrotrophs: 131 nCPM

Immune cell

basophil: 8.7 nTPM
neutrophil: 2.4 nTPM
MAIT T-cell: 2.2 nTPM
NK-cell: 1.9 nTPM
eosinophil: 1.7 nTPM
T-reg: 1.7 nTPM

Brain region

choroid plexus: 36 nTPM
cerebellum: 29 nTPM
white matter: 29 nTPM
cerebral cortex: 25 nTPM
medulla oblongata: 25 nTPM
basal ganglia: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.14
gnomAD pLI: 1
gnomAD missense Z: 1.21
DepMap mean gene effect: -1.52
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
TRAPP III complex, Trs85
TPPC8, C-terminal Ig-like domain
TPPC8, second Ig-like domain
TPPC8, third Ig-like domain
TPPC8, first Ig-like domain
ER-Golgi trafficking TRAPP I complex 85 kDa subunit
TPPC8 C-terminal Ig-like domain
TPPC8 second Ig-like domain
TPPC8 first Ig-like domain
TPPC8 third Ig-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAPPC8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAPPC8 as an antibody target. Whether an autoantibody or antibody against TRAPPC8 could matter depends on whether native TRAPPC8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAPPC8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAPPC8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...