Seroatlas · Human Serome Atlas

TRAPPC11

Trafficking protein particle complex subunit 11

Also known as: C4orf41, FLJ12716, foigr, gry, TPC11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z392
Gene: TRAPPC11
Ensembl: ENSG00000168538
Chromosome: 4
Canonical length: 1133 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgi vesicle transport. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

1133 residues, UniProt reviewed canonical sequence.

>Q7Z392|TRAPPC11
     1  MSPTQWDFPV ELCCRPMAFV TLTGLDVVYN AVHRAVWDAF CANRRADRVP ISFKVLPGDH
    61  EYPKCRPKRT SYEWYIPKGI LKTGWMNKHL NLVPALVVVF YELDWDEPQW KEKQSECATR
   121  VEIVRQSLQG RNTKVAVVLI QKKTPLPPGE DVIASERAAA LCNACELSGK SLFVLPHTDH
   181  LVGYIIRLEN AFYEHAQTYY YTEIRRVKSH KEFLNKTTHQ LLFVRHQFKI AFFSELKQDT
   241  QNALKNYRTA YNLVHELRAH ETNILEIKTM AGFINYKICR LCFQHNTPLD AIAQFRKHID
   301  LCKKKIGSAE LSFEHDAWMS KQFQAFGDLF DEAIKLGLTA IQTQNPGFYY QQAAYYAQER
   361  KQLAKTLCNH EASVMYPNPD PLETQTGVLD FYGQRSWRQG ILSFDLSDPE KEKVGILAIQ
   421  LKERNVVHSE IIITLLSNAV AQFKKYKCPR MKSHLMVQMG EEYYYAKDYT KALKLLDYVM
   481  CDYRSEGWWT LLTSVLTTAL KCSYLMAQLK DYITYSLELL GRASTLKDDQ KSRIEKNLIN
   541  VLMNESPDPE PDCDILAVKT AQKLWADRIS LAGSNIFTIG VQDFVPFVQC KAKFHAPSFH
   601  VDVPVQFDIY LKADCPHPIR FSKLCVSFNN QEYNQFCVIE EASKANEVLE NLTQGKMCLV
   661  PGKTRKLLFK FVAKTEDVGK KIEITSVDLA LGNETGRCVV LNWQGGGGDA ASSQEALQAA
   721  RSFKRRPKLP DNEVHWDSII IQASTMIISR VPNISVHLLH EPPALTNEMY CLVVTVQSHE
   781  KTQIRDVKLT AGLKPGQDAN LTQKTHVTLH GTELCDESYP ALLTDIPVGD LHPGEQLEKM
   841  LYVRCGTVGS RMFLVYVSYL INTTVEEKEI VCKCHKDETV TIETVFPFDV AVKFVSTKFE
   901  HLERVYADIP FLLMTDLLSA SPWALTIVSS ELQLAPSMTT VDQLESQVDN VILQTGESAS
   961  ECFCLQCPSL GNIEGGVATG HYIISWKRTS AMENIPIITT VITLPHVIVE NIPLHVNADL
  1021  PSFGRVRESL PVKYHLQNKT DLVQDVEISV EPSDAFMFSG LKQIRLRILP GTEQEMLYNF
  1081  YPLMAGYQQL PSLNINLLRF PNFTNQLLRR FIPTSIFVKP QGRLMDDTSI AAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAPPC11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 18 nTPM
choroid plexus: 18 nTPM
tongue: 17 nTPM
ovary: 17 nTPM
thymus: 17 nTPM
tonsil: 17 nTPM

Single-cell type

neutrophil progenitors: 123 nCPM
gonadotrophs: 114 nCPM
adrenal cortex cells: 113 nCPM
myonuclei: 94 nCPM
choroid plexus epithelial cells: 92 nCPM
lactotrophs: 85 nCPM

Immune cell

non-classical monocyte: 26 nTPM
intermediate monocyte: 15 nTPM
classical monocyte: 13 nTPM
myeloid DC: 13 nTPM
NK-cell: 10 nTPM
eosinophil: 8.3 nTPM

Brain region

choroid plexus: 48 nTPM
cerebellum: 32 nTPM
cerebral cortex: 28 nTPM
white matter: 27 nTPM
basal ganglia: 27 nTPM
hypothalamus: 26 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRAPPC11.

Disease | AllUniProt

Conditions TRAPPC11 is implicated in, by any mechanism.

Muscular dystrophy, limb-girdle, autosomal recessive 18 (LGMDR18) MIM:615356

Disease | GeneticClinVar

70 pathogenic / likely-pathogenic of 1,097 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Autosomal recessive limb-girdle muscular dystrophy type R18
Autosomal recessive limb-girdle muscular dystrophy
Inborn genetic diseases
Limb-girdle muscular dystrophy
Muscular dystrophy, limb-girdle, autosomal recessive 23

Disease | ImmuneIEDB

Conditions an epitope on TRAPPC11 was assayed in.

pancreatic ductal adenocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0
gnomAD missense Z: 0.93
DepMap mean gene effect: -1.04
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Trafficking protein particle complex subunit 11
Trafficking protein particle complex subunit 11, C-terminal
Foie gras liver health family 1
Gryzun, putative Golgi trafficking

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAPPC11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAPPC11 as an antibody target. Whether an autoantibody or antibody against TRAPPC11 could matter depends on whether native TRAPPC11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAPPC11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAPPC11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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