Seroatlas · Human Serome Atlas

TRAPPC4

Trafficking protein particle complex subunit 4

Also known as: PTD009, SBDN, TPPC4_HUMAN, TRS23

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y296
Gene
TRAPPC4
Ensembl
ENSG00000196655
Chromosome
11
Canonical length
219 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Involved in autophagy and endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPP complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>Q9Y296|TRAPPC4
     1  MAIFSVYVVN KAGGLIYQLD SYAPRAEAEK TFSYPLDLLL KLHDERVLVA FGQRDGIRVG
    61  HAVLAINGMD VNGRYTADGK EVLEYLGNPA NYPVSIRFGR PRLTSNEKLM LASMFHSLFA
   121  IGSQLSPEQG SSGIEMLETD TFKLHCYQTL TGIKFVVLAD PRQAGIDSLL RKIYEIYSDF
   181  ALKNPFYSLE MPIRCELFDQ NLKLALEVAE KAGTFGPGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAPPC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 37 nTPM
  • adrenal gland: 36 nTPM
  • kidney: 35 nTPM
  • testis: 28 nTPM
  • pituitary gland: 28 nTPM
  • hypothalamus: 27 nTPM

Single-cell type

  • late primary spermatocytes: 57 nCPM
  • differentiating spermatogonia: 39 nCPM
  • parietal cells: 32 nCPM
  • undifferentiated spermatogonia: 30 nCPM
  • early spermatids: 27 nCPM
  • early primary spermatocytes: 27 nCPM

Immune cell

  • T-reg: 97 nTPM
  • eosinophil: 77 nTPM
  • basophil: 69 nTPM
  • total PBMC: 61 nTPM
  • memory CD4 T-cell: 60 nTPM
  • memory CD8 T-cell: 60 nTPM

Brain region

  • hypothalamus: 8.7 nTPM
  • white matter: 7.9 nTPM
  • choroid plexus: 6 nTPM
  • medulla oblongata: 6 nTPM
  • spinal cord: 5.9 nTPM
  • cerebellum: 5.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRAPPC4.

Disease | AllUniProt

Conditions TRAPPC4 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with epilepsy, spasticity, and brain atrophy (NEDESBA) MIM:618741

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 83 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on TRAPPC4 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.48
gnomAD pLI
0
gnomAD missense Z
0.43
DepMap mean gene effect
-0.88
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAPPC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAPPC4 as an antibody target. Whether an autoantibody or antibody against TRAPPC4 could matter depends on whether native TRAPPC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAPPC4 is annotated at the cell surface, where native TRAPPC4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRAPPC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRAPPC4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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