Seroatlas · Human Serome Atlas

TRAPPC3

Trafficking protein particle complex subunit 3

Also known as: BET3, TPPC3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43617
Gene
TRAPPC3
Ensembl
ENSG00000054116
Chromosome
1
Canonical length
180 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. The encoded protein participates in the regulation of transport from the endoplasmic reticulum to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

180 residues, UniProt reviewed canonical sequence.

>O43617|TRAPPC3
     1  MSRQANRGTE SKKMSSELFT LTYGALVTQL CKDYENDEDV NKQLDKMGFN IGVRLIEDFL
    61  ARSNVGRCHD FRETADVIAK VAFKMYLGIT PSITNWSPAG DEFSLILENN PLVDFVELPD
   121  NHSSLIYSNL LCGVLRGALE MVQMAVEAKF VQDTLKGDGV TEIRMRFIRR IEDNLPAGEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAPPC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
84 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 84 nTPM
  • adrenal gland: 69 nTPM
  • esophagus: 58 nTPM
  • epididymis: 57 nTPM
  • thyroid gland: 56 nTPM
  • colon: 52 nTPM

Single-cell type

  • esophageal apical cells: 476 nCPM
  • late primary spermatocytes: 385 nCPM
  • esophageal suprabasal cells: 265 nCPM
  • early spermatids: 260 nCPM
  • syncytiotrophoblasts: 238 nCPM
  • extravillous trophoblasts: 177 nCPM

Immune cell

  • basophil: 163 nTPM
  • total PBMC: 155 nTPM
  • eosinophil: 149 nTPM
  • intermediate monocyte: 143 nTPM
  • T-reg: 136 nTPM
  • neutrophil: 135 nTPM

Brain region

  • choroid plexus: 53 nTPM
  • white matter: 43 nTPM
  • medulla oblongata: 42 nTPM
  • spinal cord: 41 nTPM
  • cerebellum: 39 nTPM
  • hypothalamus: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRAPPC3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 54 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0.25
gnomAD missense Z
1.2
DepMap mean gene effect
-1.58
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAPPC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAPPC3 as an antibody target. Whether an autoantibody or antibody against TRAPPC3 could matter depends on whether native TRAPPC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAPPC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAPPC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRAPPC3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...