Seroatlas · Human Serome Atlas

TRAPPC2L

Trafficking protein particle complex subunit 2-like protein

Also known as: HSPC176, TPC2L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UL33
Gene: TRAPPC2L
Ensembl: ENSG00000167515
Chromosome: 16
Canonical length: 140 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a protein that interacts with the tethering factor trafficking protein particle (TRAPP complex). TRAPP complexes mediate the contact between vescicles and target membranes, and thus, are involved in vescicle-mediated transport of proteins and lipids. The encoded protein is related to the X-linked trafficking protein particle complex 2. A related pseudogene is located on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>Q9UL33|TRAPPC2L
     1  MAVCIAVIAK ENYPLYIRST PTENELKFHY MVHTSLDVVD EKISAMGKAL VDQRELYLGL
    61  LYPTEDYKVY GYVTNSKVKF VMVVDSSNTA LRDNEIRSMF RKLHNSYTDV MCNPFYNPGD
   121  RIQSSRAFDN MVTSMMIQVC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAPPC2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 119 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 119 nTPM
choroid plexus: 114 nTPM
testis: 113 nTPM
skeletal muscle: 91 nTPM
spinal cord: 74 nTPM
amygdala: 68 nTPM

Single-cell type

late spermatids: 631 nCPM
late primary spermatocytes: 471 nCPM
hofbauer cells: 330 nCPM
esophageal suprabasal cells: 261 nCPM
parietal cells: 223 nCPM
oocytes: 221 nCPM

Immune cell

T-reg: 179 nTPM
total PBMC: 164 nTPM
plasmacytoid DC: 163 nTPM
memory B-cell: 155 nTPM
naive B-cell: 139 nTPM
classical monocyte: 137 nTPM

Brain region

white matter: 48 nTPM
hypothalamus: 42 nTPM
spinal cord: 36 nTPM
pons: 35 nTPM
midbrain: 33 nTPM
cerebral cortex: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRAPPC2L.

Disease | AllUniProt

Conditions TRAPPC2L is implicated in, by any mechanism.

Encephalopathy, progressive, early-onset, with episodic rhabdomyolysis (PEERB) MIM:618331

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 72 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Encephalopathy, progressive, early-onset, with episodic rhabdomyolysis
Colon adenocarcinoma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0
gnomAD missense Z: -0.38
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Trafficking protein particle complex subunit 2
Longin-like domain superfamily
Sedlin, N-terminal conserved region
Trafficking protein particle complex subunit 2-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAPPC2L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAPPC2L as an antibody target. Whether an autoantibody or antibody against TRAPPC2L could matter depends on whether native TRAPPC2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAPPC2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAPPC2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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